Olaratumab: PDGFR-Î± inhibition as a novel tool in the treatment of advanced soft tissue sarcomas

Antonio Russo; Giuseppe Badalamenti; Francesco Pantano; Massimo Aglietta; Andrea Napolitano; Mariella Spalato Ceruso; Bruno Vincenzi; Giovanni Grignani; Giuseppe Tonini; Daniele Santini; Daniele Santini

Olaratumab: PDGFR-Î± inhibition as a novel tool in the treatment of advanced soft tissue sarcomas

Antonio Russo, Giuseppe Badalamenti, Francesco Pantano, Massimo Aglietta, Andrea Napolitano, Mariella Spalato Ceruso, Bruno Vincenzi, Giovanni Grignani, Giuseppe Tonini, Daniele Santini, Daniele Santini

Discipline Chirurgiche, Oncologiche e Stomatologiche

Risultato della ricerca: Article › peer review

11 Citazioni (Scopus)

Abstract

Advanced soft tissue sarcomas are aggressive cancers with limited therapeutic options. Recently, inhibition of platelet-derived growth factor receptor (PDGFR)-Î± by the monoclonal antibody olaratumab showed promising clinical activity. If confirmed, this would be one of the first examples of targeted therapy effective in advanced soft tissue sarcomas therapy independently of the histologic subtype. Here, we reviewed the biology of the PDGF/PDGFR axis, particularly focusing on its role in cancer, and then we discussed on the effects of PDGFR-Î± inhibition in the therapy of advanced soft tissue sarcomas.

Lingua originale	English
pagine (da-a)	1-6
Numero di pagine	6
Rivista	CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume	118
Stato di pubblicazione	Published - 2017

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Geriatrics and Gerontology

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Olaratumab: PDGFR-Î± inhibition as a novel tool in the treatment of advanced soft tissue sarcomas. / Russo, Antonio ; Badalamenti, Giuseppe; Pantano, Francesco; Aglietta, Massimo; Napolitano, Andrea; Spalato Ceruso, Mariella; Vincenzi, Bruno; Grignani, Giovanni; Tonini, Giuseppe; Santini, Daniele; Santini, Daniele.

In: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, Vol. 118, 2017, pag. 1-6.

Risultato della ricerca: Article › peer review

Russo, Antonio ; Badalamenti, Giuseppe ; Pantano, Francesco ; Aglietta, Massimo ; Napolitano, Andrea ; Spalato Ceruso, Mariella ; Vincenzi, Bruno ; Grignani, Giovanni ; Tonini, Giuseppe ; Santini, Daniele ; Santini, Daniele. / Olaratumab: PDGFR-Î± inhibition as a novel tool in the treatment of advanced soft tissue sarcomas. In: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 2017 ; Vol. 118. pagg. 1-6.

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T1 - Olaratumab: PDGFR-Î± inhibition as a novel tool in the treatment of advanced soft tissue sarcomas

AU - Russo, Antonio

AU - Badalamenti, Giuseppe

AU - Pantano, Francesco

AU - Aglietta, Massimo

AU - Napolitano, Andrea

AU - Spalato Ceruso, Mariella

AU - Vincenzi, Bruno

AU - Grignani, Giovanni

AU - Tonini, Giuseppe

AU - Santini, Daniele

PY - 2017

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AB - Advanced soft tissue sarcomas are aggressive cancers with limited therapeutic options. Recently, inhibition of platelet-derived growth factor receptor (PDGFR)-Î± by the monoclonal antibody olaratumab showed promising clinical activity. If confirmed, this would be one of the first examples of targeted therapy effective in advanced soft tissue sarcomas therapy independently of the histologic subtype. Here, we reviewed the biology of the PDGF/PDGFR axis, particularly focusing on its role in cancer, and then we discussed on the effects of PDGFR-Î± inhibition in the therapy of advanced soft tissue sarcomas.

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KW - Geriatrics and Gerontology

KW - Hematology

KW - Olaratumab

KW - Oncology

KW - PDGFR-Î±

KW - Soft tissue sarcomas

KW - Doxorubicin

KW - Geriatrics and Gerontology

KW - Hematology

KW - Olaratumab

KW - Oncology

KW - PDGFR-Î±

KW - Soft tissue sarcomas

UR - http://hdl.handle.net/10447/246543

UR - http://www.elsevier.com/locate/critrevonc

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