Occult hepatitis B virus in liver tissue of individuals without hepatic disease.

Gaetano Giuseppe Di Vita, Stefania Mondello, Lucy Costantino, Giovanni Raimondo, Claudio Scisca, Guido Colloredo, Teresa Pollicino, Eugenio Cucinotta, Giuseppe Navarra, Giovanni Squadrito

Risultato della ricerca: Article

139 Citazioni (Scopus)

Abstract

AbstractBACKGROUND/AIMS: While many data are available concerning occult hepatitis B virus (HBV) infection in patients with hepatic disorders, there is little information about this cryptic infection in individuals without liver disease. The aim of this study was to investigate the prevalence of occult HBV in the general population by examining liver specimens from a large series of HBV-surface-antigen negative individuals with no clinical and biochemical evidence of liver disease.METHODS: The presence of HBV DNA was evaluated by testing, through polymerase chain reaction techniques, DNA extracts from 98 liver-disease-free individuals who underwent liver resection or needle biopsy during abdominal surgery. Sixteen of them were anti-HBV-core antigen (anti-HBc) positive and 82 were HBV serum-marker negative. All patients were negative for antibody to hepatitis C virus.RESULTS: Occult HBV infection was revealed in 16 of the 98 cases (16.3%). In particular, 10/16 anti-HBc positive (62.5%) versus 6/82 (7.3%) HBV-seronegative individuals were occult carriers (p<0.0001).CONCLUSIONS: This study revealed that about 1/6 of the Italian general population might be carriers of occult HBV infection, and this condition is significantly associated with the anti-HBc positive status.
Lingua originaleEnglish
pagine (da-a)743-746
Numero di pagine4
RivistaJournal of Hepatology
Volume48
Stato di pubblicazionePublished - 2008

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Hepatitis B virus
Liver
Virus Diseases
Liver Diseases
Hepatitis B Core Antigens
Antigens
Hepatitis C Antibodies
DNA
Needle Biopsy
Hepatitis B Surface Antigens
Population
Biomarkers
Polymerase Chain Reaction
Infection

All Science Journal Classification (ASJC) codes

  • Hepatology

Cita questo

Di Vita, G. G., Mondello, S., Costantino, L., Raimondo, G., Scisca, C., Colloredo, G., ... Squadrito, G. (2008). Occult hepatitis B virus in liver tissue of individuals without hepatic disease. Journal of Hepatology, 48, 743-746.

Occult hepatitis B virus in liver tissue of individuals without hepatic disease. / Di Vita, Gaetano Giuseppe; Mondello, Stefania; Costantino, Lucy; Raimondo, Giovanni; Scisca, Claudio; Colloredo, Guido; Pollicino, Teresa; Cucinotta, Eugenio; Navarra, Giuseppe; Squadrito, Giovanni.

In: Journal of Hepatology, Vol. 48, 2008, pag. 743-746.

Risultato della ricerca: Article

Di Vita, GG, Mondello, S, Costantino, L, Raimondo, G, Scisca, C, Colloredo, G, Pollicino, T, Cucinotta, E, Navarra, G & Squadrito, G 2008, 'Occult hepatitis B virus in liver tissue of individuals without hepatic disease.', Journal of Hepatology, vol. 48, pagg. 743-746.
Di Vita GG, Mondello S, Costantino L, Raimondo G, Scisca C, Colloredo G e altri. Occult hepatitis B virus in liver tissue of individuals without hepatic disease. Journal of Hepatology. 2008;48:743-746.
Di Vita, Gaetano Giuseppe ; Mondello, Stefania ; Costantino, Lucy ; Raimondo, Giovanni ; Scisca, Claudio ; Colloredo, Guido ; Pollicino, Teresa ; Cucinotta, Eugenio ; Navarra, Giuseppe ; Squadrito, Giovanni. / Occult hepatitis B virus in liver tissue of individuals without hepatic disease. In: Journal of Hepatology. 2008 ; Vol. 48. pagg. 743-746.
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abstract = "AbstractBACKGROUND/AIMS: While many data are available concerning occult hepatitis B virus (HBV) infection in patients with hepatic disorders, there is little information about this cryptic infection in individuals without liver disease. The aim of this study was to investigate the prevalence of occult HBV in the general population by examining liver specimens from a large series of HBV-surface-antigen negative individuals with no clinical and biochemical evidence of liver disease.METHODS: The presence of HBV DNA was evaluated by testing, through polymerase chain reaction techniques, DNA extracts from 98 liver-disease-free individuals who underwent liver resection or needle biopsy during abdominal surgery. Sixteen of them were anti-HBV-core antigen (anti-HBc) positive and 82 were HBV serum-marker negative. All patients were negative for antibody to hepatitis C virus.RESULTS: Occult HBV infection was revealed in 16 of the 98 cases (16.3{\%}). In particular, 10/16 anti-HBc positive (62.5{\%}) versus 6/82 (7.3{\%}) HBV-seronegative individuals were occult carriers (p<0.0001).CONCLUSIONS: This study revealed that about 1/6 of the Italian general population might be carriers of occult HBV infection, and this condition is significantly associated with the anti-HBc positive status.",
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T1 - Occult hepatitis B virus in liver tissue of individuals without hepatic disease.

AU - Di Vita, Gaetano Giuseppe

AU - Mondello, Stefania

AU - Costantino, Lucy

AU - Raimondo, Giovanni

AU - Scisca, Claudio

AU - Colloredo, Guido

AU - Pollicino, Teresa

AU - Cucinotta, Eugenio

AU - Navarra, Giuseppe

AU - Squadrito, Giovanni

PY - 2008

Y1 - 2008

N2 - AbstractBACKGROUND/AIMS: While many data are available concerning occult hepatitis B virus (HBV) infection in patients with hepatic disorders, there is little information about this cryptic infection in individuals without liver disease. The aim of this study was to investigate the prevalence of occult HBV in the general population by examining liver specimens from a large series of HBV-surface-antigen negative individuals with no clinical and biochemical evidence of liver disease.METHODS: The presence of HBV DNA was evaluated by testing, through polymerase chain reaction techniques, DNA extracts from 98 liver-disease-free individuals who underwent liver resection or needle biopsy during abdominal surgery. Sixteen of them were anti-HBV-core antigen (anti-HBc) positive and 82 were HBV serum-marker negative. All patients were negative for antibody to hepatitis C virus.RESULTS: Occult HBV infection was revealed in 16 of the 98 cases (16.3%). In particular, 10/16 anti-HBc positive (62.5%) versus 6/82 (7.3%) HBV-seronegative individuals were occult carriers (p<0.0001).CONCLUSIONS: This study revealed that about 1/6 of the Italian general population might be carriers of occult HBV infection, and this condition is significantly associated with the anti-HBc positive status.

AB - AbstractBACKGROUND/AIMS: While many data are available concerning occult hepatitis B virus (HBV) infection in patients with hepatic disorders, there is little information about this cryptic infection in individuals without liver disease. The aim of this study was to investigate the prevalence of occult HBV in the general population by examining liver specimens from a large series of HBV-surface-antigen negative individuals with no clinical and biochemical evidence of liver disease.METHODS: The presence of HBV DNA was evaluated by testing, through polymerase chain reaction techniques, DNA extracts from 98 liver-disease-free individuals who underwent liver resection or needle biopsy during abdominal surgery. Sixteen of them were anti-HBV-core antigen (anti-HBc) positive and 82 were HBV serum-marker negative. All patients were negative for antibody to hepatitis C virus.RESULTS: Occult HBV infection was revealed in 16 of the 98 cases (16.3%). In particular, 10/16 anti-HBc positive (62.5%) versus 6/82 (7.3%) HBV-seronegative individuals were occult carriers (p<0.0001).CONCLUSIONS: This study revealed that about 1/6 of the Italian general population might be carriers of occult HBV infection, and this condition is significantly associated with the anti-HBc positive status.

KW - hepatitis B virus

KW - liver tissue

UR - http://hdl.handle.net/10447/59154

M3 - Article

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SP - 743

EP - 746

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

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