Background and objective: Obstructive sleep apnoea(OSA) and dyslipidaemia are independent risk factorsfor cardiovascular disease. This study investigates theassociation between OSA and plasma lipid concentrationsin patients enrolled in the European Sleep ApneaDatabase (ESADA) cohort.Methods: The cross-sectional analysis included 8592patients without physician-diagnosed hyperlipidaemiaor reported intake of a lipid-lowering drug (age50.1 12.7 years, 69.1% male, BMI: 30.8 6.6 kg/m2,mean apnoea–hypopnoea index (AHI): 25.7 25.9events/h). The independent relationship between measuresof OSA (AHI, oxygen desaturation index (ODI),mean and lowest oxygen saturation) and lipid profile(total cholesterol (TC), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C) and fasting triglycerides (TG)) was determinedby means of general linear model analysis.Results: There was a dose response relationshipbetween TC and ODI (mean SE (mg/dL):180.33 2.46, 184.59 2.42, 185.44 2.42 and185.73 2.44; P < 0.001 across ODI quartiles I–IV). TGand LDL concentrations were better predicted by AHIthan by ODI. HDL-C was significantly reduced in thehighest AHI quartile (mean SE (mg/dL): 48.8 1.49vs 46.50 1.48; P = 0.002, AHI quartile I vs IV). Morbidobesity was associated with lower TC and higher HDL-Cvalues. Lipid status was influenced by geographical locationwith the highest TC concentration recorded inNorthern Europe.Conclusion: OSA severity was independently associatedwith cholesterol and TG concentrations.
|Numero di pagine||10|
|Stato di pubblicazione||Published - 2018|