Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database.

Maria Rosaria Bonsignore, Athanasia Pataka, Pataka, Ulla Anttalainen, Mehmet S. Tasbakan, Gabriel Roisman, Bouloukaki, Parati, Jan Hedner, Jean-Louis Pepin, Maria R. Bonsignore, Mcnicholas, Pavel Sliwinski, Sofia Schiza, Brian D. Kent, Varoneckas, Ding Zou, Kvamme, Steiropoulos, BielickiTkacova, Canan Gündüz, Zuzana Dorkova, Escourrou, Barbé, Ozen K. Basoglu, Schulz, Jean Lois Pepin, Erna Petiet, Sliwinski, Pataka, Richard Staats, Vitols, Josep M. Montserrat, Ludger Grote, Hein, Parati, Varoneckas, Riha, Staats, Pretl, Dogas, Plywaczewski, Saaresranta, Verbraecken, Masa, Marrone, Fietze, Jan Hedner, Hedner, Penzel, Ludger Grote, Grote, Ferran Barbe, Carolina Lombardi, Holger Hein, Levy, Basoglu, Joppa, Pépin, Silke Ryan

Risultato della ricerca: Article

16 Citazioni (Scopus)

Abstract

Background and objective: Obstructive sleep apnoea(OSA) and dyslipidaemia are independent risk factorsfor cardiovascular disease. This study investigates theassociation between OSA and plasma lipid concentrationsin patients enrolled in the European Sleep ApneaDatabase (ESADA) cohort.Methods: The cross-sectional analysis included 8592patients without physician-diagnosed hyperlipidaemiaor reported intake of a lipid-lowering drug (age50.1 12.7 years, 69.1% male, BMI: 30.8 6.6 kg/m2,mean apnoea–hypopnoea index (AHI): 25.7 25.9events/h). The independent relationship between measuresof OSA (AHI, oxygen desaturation index (ODI),mean and lowest oxygen saturation) and lipid profile(total cholesterol (TC), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C) and fasting triglycerides (TG)) was determinedby means of general linear model analysis.Results: There was a dose response relationshipbetween TC and ODI (mean SE (mg/dL):180.33 2.46, 184.59 2.42, 185.44 2.42 and185.73 2.44; P < 0.001 across ODI quartiles I–IV). TGand LDL concentrations were better predicted by AHIthan by ODI. HDL-C was significantly reduced in thehighest AHI quartile (mean SE (mg/dL): 48.8 1.49vs 46.50 1.48; P = 0.002, AHI quartile I vs IV). Morbidobesity was associated with lower TC and higher HDL-Cvalues. Lipid status was influenced by geographical locationwith the highest TC concentration recorded inNorthern Europe.Conclusion: OSA severity was independently associatedwith cholesterol and TG concentrations.
Lingua originaleEnglish
pagine (da-a)1180-1189
Numero di pagine10
RivistaRespirology
Volume23
Stato di pubblicazionePublished - 2018

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All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cita questo

Bonsignore, M. R., Pataka, A., Pataka, Anttalainen, U., Tasbakan, M. S., Roisman, G., Bouloukaki, Parati, Hedner, J., Pepin, J-L., Bonsignore, M. R., Mcnicholas, Sliwinski, P., Schiza, S., Kent, B. D., Varoneckas, Zou, D., Kvamme, Steiropoulos, ... Ryan, S. (2018). Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database. Respirology, 23, 1180-1189.