Obesity and Circulating Levels of Vitamin D before and after Weight Loss Induced by a Very Low-Calorie Ketogenic Diet

Antonio Maria Borzi', Silvio Buscemi, Marcello Ciaccio, Marcello Ciaccio, Anna Maria Barile, Giuseppe Rosafio, Valentina Settipani, Carola Buscemi, Davide Corleo, Antonio Maria Borzì, Francesco Meli, Cristiana Randazzo, Sabina Gurrera, Salvatore Milazzo, Rosalia Caldarella, Silvio Buscemi, Giovanni De Pergola, Anna Maria Barile, Cristiana Randazzo, Davide CorleoFrancesco Meli, Giuseppe Rosafio, Rosalia Caldarella, Salvatore Milazzo, Valentina Settipani

Risultato della ricerca: Articlepeer review


Background: Vitamin D plays a pivotal role in calcium and phosphorus metabolism, also influencing bone tissue. Several studies have reported that vitamin D blood levels were significantly lower in people with obesity, probably due to its uptake by the adipose tissue. Clinical studies that investigated the changes of circulating levels of vitamin D following weight loss reported controversial data. A very low-calorie ketogenic diet is acknowledged as a reliable treatment to achieve a rapid weight loss. Therefore, we investigated the effect of weight loss, consequent to a very low-calorie ketogenic diet, on vitamin D blood concentrations. Methods: A cohort of 31 people with obesity underwent a very low-calorie ketogenic diet for 10-12 weeks. The serum concentrations of vitamin D, parathormone, calcium and phosphorous were measured before and after weight loss; they were compared to a control group of 20 non-obese, non-diabetic, age- and gender-matched persons. Results: Patients with obesity had a higher habitual intake of vitamin D than the control group (p < 0.05). However, the vitamin D blood levels of the obese group were significantly lower than those of the control group (p < 0.005) and they increased after weight loss (p < 0.001). At baseline, vitamin D blood concentrations of the persons with obesity were significantly correlated with both fat mass-kg (r = -0.40; p < 0.05) and body mass index (r = -0.47; p < 0.01). Following very low-calorie ketogenic diet, the change in vitamin D serum concentrations was correlated only with the change in fat mass-kg (r = -0.43; p < 0.01). Conclusion: This study confirmed that patients with obesity have lower vitamin D levels that normalize after significant weight loss, supporting the hypothesis that vitamin D is stored in the adipose tissue and released following weight loss.
Lingua originaleEnglish
pagine (da-a)1-9
Numero di pagine9
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.1100.1106???
  • ???subjectarea.asjc.2900.2916???


Entra nei temi di ricerca di 'Obesity and Circulating Levels of Vitamin D before and after Weight Loss Induced by a Very Low-Calorie Ketogenic Diet'. Insieme formano una fingerprint unica.

Cita questo