TY - JOUR
T1 - Nutrition and lipidomic profile in colorectal cancers
AU - Veronese, Nicola
AU - Tutino, Valeria
AU - Stasi, Elisa
AU - Veronese, Nicola
AU - Reddavide, Rosa
AU - Caruso, Maria Gabriella
AU - Gigante, Isabella
AU - De Nunzio, Valentina
AU - De Leonardis, Giampiero
AU - Rotolo, Ornella
AU - Miraglia, Chiara
AU - De’ Angelis, Gian Luigi
AU - Nouvenne, Antonio
AU - Meschi, Tiziana
AU - Notarnicola, Maria
AU - Leandro, Gioacchino
AU - Di Mario, Francesco
PY - 2018
Y1 - 2018
N2 - Background: Adherence to a healthy diet has been reported to be essential for the primary prevention of colorectal cancer, through a reduction of tissue inflammation, a low concentration of circulating lipoproteins and lower levels of serum cholesterol. Since an altered expression of the fatty acids pattern has been demonstrated to be a crucial event in colorectal carcinogenesis, lipidomic analysis is considered able to identify early diagnostic and prognostic biomarkers of complex diseases such as colorectal cancer. Methods: cell membrane fatty acid profile and serum lipoproteins pattern were evaluated by gas chromatography and electrophoresis method respectively. Results: There is a close association between diet and lipidomic profile in colorectal cancer, both in pre-clinical and clinical studies. A modified serum lipoproteins pattern has been demonstrated to be predominant in intestinal tumors. Conclusions: The study of fatty acids profile in cell membrane and the evaluation of serum lipoproteins subfractions could be useful to have an integrate vision on the interactions between lipids and the pathogenesis of colorectal cancer and to understand the mechanisms of action and the consequences of these interactions on human health status. (www.actabiomedica.it). © Mattioli 1885.
AB - Background: Adherence to a healthy diet has been reported to be essential for the primary prevention of colorectal cancer, through a reduction of tissue inflammation, a low concentration of circulating lipoproteins and lower levels of serum cholesterol. Since an altered expression of the fatty acids pattern has been demonstrated to be a crucial event in colorectal carcinogenesis, lipidomic analysis is considered able to identify early diagnostic and prognostic biomarkers of complex diseases such as colorectal cancer. Methods: cell membrane fatty acid profile and serum lipoproteins pattern were evaluated by gas chromatography and electrophoresis method respectively. Results: There is a close association between diet and lipidomic profile in colorectal cancer, both in pre-clinical and clinical studies. A modified serum lipoproteins pattern has been demonstrated to be predominant in intestinal tumors. Conclusions: The study of fatty acids profile in cell membrane and the evaluation of serum lipoproteins subfractions could be useful to have an integrate vision on the interactions between lipids and the pathogenesis of colorectal cancer and to understand the mechanisms of action and the consequences of these interactions on human health status. (www.actabiomedica.it). © Mattioli 1885.
UR - http://hdl.handle.net/10447/454118
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058743273&doi=10.23750/abm.v89i9-S.7955&partnerID=40&md5=ee1f399fffffc19a477ebaab4570cff1
M3 - Article
VL - 89
SP - 87
EP - 96
JO - ACTA BIOMEDICA
JF - ACTA BIOMEDICA
SN - 2531-6745
ER -