Nucleophilic substitutions in the isoindole series as a valuable tool to synthesizederivatives with antitumor activity

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13 Citazioni (Scopus)

Abstract

A novel synthetic approach to the synthesis of 3-substituted isoindoles through nucleophilic substitution of 3-halo derivatives by charged carbon, and neutral nitrogen, oxygen, and sulfur nucleophiles, assisted by a 1-acyl group, is reported. Aryl-thio-isoindoles, obtained through a direct nucleophilic substitution with sulfur nucleophiles, showed cytotoxic activity, with GI50 values from micromolar to sub-micromolar concentrations, against the total number of cell lines investigated.
Lingua originaleEnglish
pagine (da-a)2072-2080
Numero di pagine9
RivistaTetrahedron
Volume67
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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