The correlation between liver stiffness, measured by transient elastography,liver fibrosis, using the histological METAVIR score, and iron overload,measured by atomic absorption spectrometry was evaluated in 56homozygous-b-thalassaemics. Liver stiffness increased proportionally toliver fibrosis staging (r = 0Æ70; P > 0Æ001) independently of liver ironconcentration (r = 0Æ01; P = 0Æ932). The area under the receiver-operatingcharacteristic curve for prediction of cirrhosis was 0Æ997 (95% confidenceinterval [CI]: 0Æ925–1Æ000) with cut-off of 13 kPa with 100% sensitivity (95%CI: 69Æ0–100Æ0) and 95% specificity (95% CI: 84Æ2–99Æ3). Transientelastography is a reliable non-invasive tool for diagnosing advanced liverfibrosis in homozygous-b-thalassaemics, regardless of the degree of ironoverload.
|Numero di pagine||4|
|Rivista||British Journal of Haematology|
|Stato di pubblicazione||Published - 2009|
All Science Journal Classification (ASJC) codes
Di Marco, V., Bronte, F., Cabibi, D., Almasio, P. L., Calvaruso, V., Craxi, A., Gagliardotto, F., Borsellino, Z., Capra, M., & Alaimo, G. (2009). Noninvasive assessment of liver fibrosis in thalassaemia major patients by transient elastography (TE) - lack of interference by iron deposition. British Journal of Haematology, 2009-11-23, 476-479.