Noninvasive assessment of liver fibrosis in thalassaemia major patients by transient elastography (TE) - lack of interference by iron deposition.

Vito Di Marco, Fabrizio Bronte, Daniela Cabibi, Pier Luigi Almasio, Vincenza Calvaruso, Antonio Craxi, Francesco Gagliardotto, Zelia Borsellino, Marcello Capra, Giuseppe Alaimo

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42 Citazioni (Scopus)

Abstract

The correlation between liver stiffness, measured by transient elastography,liver fibrosis, using the histological METAVIR score, and iron overload,measured by atomic absorption spectrometry was evaluated in 56homozygous-b-thalassaemics. Liver stiffness increased proportionally toliver fibrosis staging (r = 0Æ70; P > 0Æ001) independently of liver ironconcentration (r = 0Æ01; P = 0Æ932). The area under the receiver-operatingcharacteristic curve for prediction of cirrhosis was 0Æ997 (95% confidenceinterval [CI]: 0Æ925–1Æ000) with cut-off of 13 kPa with 100% sensitivity (95%CI: 69Æ0–100Æ0) and 95% specificity (95% CI: 84Æ2–99Æ3). Transientelastography is a reliable non-invasive tool for diagnosing advanced liverfibrosis in homozygous-b-thalassaemics, regardless of the degree of ironoverload.
Lingua originaleEnglish
pagine (da-a)476-479
Numero di pagine4
RivistaBritish Journal of Haematology
Volume2009-11-23
Stato di pubblicazionePublished - 2009

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All Science Journal Classification (ASJC) codes

  • Hematology

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