Non-flavonoid Polyphenols in Osteoporosis: Preclinical Evidence

Fabio Caradonna, Carla Gentile, Daniele Bellavia, Angela De Luca, Valeria Carina, Viviana Costa, Gianluca Giavaresi, Gianluca Giavaresi, Lavinia Raimondi, Milena Fini

Risultato della ricerca: Articlepeer review

Abstract

The development of progressive osteopenia and osteoporosis (OP) is due to the imbalance between bone resorption and bone formation, determining a lower bone resistance, major risks of fractures, with consequent pain and functional limitations. Flavonoids, a class of polyphenols, have been extensively studied for their therapeutic activities against bone resorption, but less attention has been given to a whole series of molecules belonging to the polyphenolic compounds. However, these classes have begun to be studied for the treatment of OP. In this systematic review, comprehensive information is provided on non-flavonoid polyphenolic compounds, and we highlight pathways implicated in the action of these molecules that act often epigenetically, and their possible use for OP treatment and prevention.
Lingua originaleEnglish
pagine (da-a)1-15
Numero di pagine15
RivistaTrends in Endocrinology and Metabolism
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1310???

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