Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study.

Maria Rosaria Bonsignore, Martin Javorsky, Gianfranco Parati, Walter T. Mcnicholas, Pawel Sliwinski, Ruzena Tkacova, Gianfranco Parati, Ingo Fietze, Jan Hedner, Ludger Grote

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58 Citazioni (Scopus)

Abstract

Systemic hypertension is associated with obstructive sleep apnoea syndrome (OSAS) but the pathophysiological mechanisms are incompletely understood. A collaborative European network of 24 sleep centres established a European Sleep Apnoea Database to evaluate cardiovascular morbidity associated with OSAS. 11 911 adults referred with suspected OSAS between March 2007 and September 2013 underwent overnight sleep studies, either cardiorespiratory polygraphy or polysomnography. We compared the predictive value of the apnoea-hypopnoea index (AHI) and 4% oxygen desaturation index (ODI) for prevalent hypertension, adjusting for relevant covariates including age, smoking, obesity, dyslipidaemia and diabetes. Among patients (70% male, mean±sd age 52±12 years), 78% had AHI >5 events·h(-1) and 41% systemic hypertension. Both AHI and ODI independently related to prevalent hypertension after adjustment for relevant covariates (p<0.0001 for linear trend across quartiles (Q) of severity for both variables). However, in multiple regression analysis with both ODI and AHI in the model, ODI was, whereas AHI was not, independently associated with prevalent hypertension: odds ratios (95% CI) for Q4 versus Q1 regarding ODI were 2.01 (1.61-2.51) and regarding AHI were 0.92 (0.74-1.15) (p<0.0001 and p=0.3054, respectively). This cross sectional study suggests that chronic intermittent hypoxia plays an important role in OSAS-related hypertension.
Lingua originaleEnglish
pagine (da-a)931-941
Numero di pagine11
RivistaEuropean Respiratory Journal
Volume44
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

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    Bonsignore, M. R., Javorsky, M., Parati, G., Mcnicholas, W. T., Sliwinski, P., Tkacova, R., Parati, G., Fietze, I., Hedner, J., & Grote, L. (2014). Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study. European Respiratory Journal, 44, 931-941.