Abstract

Duchenne muscular dystrophy (DMD) is characterized by progressive skeletalmuscle weakness. We have previously shown that low-intensity endurancetraining prevented muscle damage (Frinchi et al, Int J Sports Med 2014). Sincethe effects of low-intensity endurance training on the the diaphragm in the mdxmouse model are unknown, in the same animals we investigated Cx39 proteinlevels (Western blotting) in homogenates of the diaphragm before and aftertraining. Mdx and wild-type (WT) mice were randomly assigned to sedentary(mdx-S, n=17; WT-S, n=19) or trained (mdx-EX, n=14; WT-EX, n=16)groups. Low-intensity endurance training (running on a wheel) was done 5days/week for 6 weeks at progressively increasing time (15 min to 1 h) andspeed (rpm from 16 to 24, distance covered during training sessions from 48 to288 m). Compared to our previous analysis of skeletal muscles changes ingastrocnemius and quadriceps, showing decreased muscle damage in trained vssedentary mdx mice, analysis of protein level of Cx39 showed similar values indiaphragm homogenates from sedentary and trained mdx mice.These preliminary data suggest that prevention of muscle necrosis after mildtraining does not occur in the diaphragm. As a speculation, continuous work ofdiaphragm vs intermittent work of skeletal muscle might at least partly accountfor the different results obtained in respiratory and locomotor muscle.
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2014

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