Nitric Oxide modulation of the dopaminergic nigrostriatal system: focus on nicotine action.

Arcangelo Benigno, Maurizio Casarrubea, Giuseppe Crescimanno, Ennio Esposito, Massimo Pierucci, Vincenzo Di Matteo

Risultato della ricerca: Chapter

23 Citazioni (Scopus)

Abstract

Nitric oxide (NO) signalling plays an important role in the integration of information processed by the basal ganglia nuclei. Accordingly, considerable evidence has emerged indicating a role for NO in pathophysiological conditions such as Parkinson’s disease (PD), schizophrenia and drug addiction. To further investigate the NO modulation of dopaminergic function in the basal ganglia circuitry, in this study we used in vivo electrophysiology and microdialysis in freely-moving rats. Pharmacological manipulation of the NO system did not cause any significant changes either in the basal firing rate and bursting activity of the dopamine (DA) neurons in the substantia nigra pars compacta (SNc) or in DA release in the striatum. In contrast, the disruption of endogenous NO tone was able to counteract the phasic dopaminergic activation induced by nicotine treatment in both experimental approaches. These results further support the possibility that nicotine acts via a NO mechanism and suggest a possible state-dependent facilitatory control of NO on the nigrostriatal DA pathway. Thus, NO selectively modulates the DA exocytosis associated with increased DA function
Lingua originaleEnglish
Titolo della pubblicazione ospiteThe Basal Ganglia IX
Pagine309-321
Numero di pagine23
Stato di pubblicazionePublished - 2009

Serie di pubblicazioni

NomeThe BASAL GANGLIA

Fingerprint

Nicotine
Nitric Oxide
Modulation
Dopamine
Basal Ganglia
Electrophysiology
Dopaminergic Neurons
Microdialysis
Exocytosis
Neurons
Substance-Related Disorders
Parkinson Disease
Rats
Schizophrenia
Chemical activation
Pharmacology
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cita questo

Benigno, A., Casarrubea, M., Crescimanno, G., Esposito, E., Pierucci, M., & Di Matteo, V. (2009). Nitric Oxide modulation of the dopaminergic nigrostriatal system: focus on nicotine action. In The Basal Ganglia IX (pagg. 309-321). (The BASAL GANGLIA).

Nitric Oxide modulation of the dopaminergic nigrostriatal system: focus on nicotine action. / Benigno, Arcangelo; Casarrubea, Maurizio; Crescimanno, Giuseppe; Esposito, Ennio; Pierucci, Massimo; Di Matteo, Vincenzo.

The Basal Ganglia IX. 2009. pag. 309-321 (The BASAL GANGLIA).

Risultato della ricerca: Chapter

Benigno, A, Casarrubea, M, Crescimanno, G, Esposito, E, Pierucci, M & Di Matteo, V 2009, Nitric Oxide modulation of the dopaminergic nigrostriatal system: focus on nicotine action. in The Basal Ganglia IX. The BASAL GANGLIA, pagg. 309-321.
Benigno A, Casarrubea M, Crescimanno G, Esposito E, Pierucci M, Di Matteo V. Nitric Oxide modulation of the dopaminergic nigrostriatal system: focus on nicotine action. In The Basal Ganglia IX. 2009. pag. 309-321. (The BASAL GANGLIA).
Benigno, Arcangelo ; Casarrubea, Maurizio ; Crescimanno, Giuseppe ; Esposito, Ennio ; Pierucci, Massimo ; Di Matteo, Vincenzo. / Nitric Oxide modulation of the dopaminergic nigrostriatal system: focus on nicotine action. The Basal Ganglia IX. 2009. pagg. 309-321 (The BASAL GANGLIA).
@inbook{6c6d74291fa142f0a4f39eb928f7a8c7,
title = "Nitric Oxide modulation of the dopaminergic nigrostriatal system: focus on nicotine action.",
abstract = "Nitric oxide (NO) signalling plays an important role in the integration of information processed by the basal ganglia nuclei. Accordingly, considerable evidence has emerged indicating a role for NO in pathophysiological conditions such as Parkinson’s disease (PD), schizophrenia and drug addiction. To further investigate the NO modulation of dopaminergic function in the basal ganglia circuitry, in this study we used in vivo electrophysiology and microdialysis in freely-moving rats. Pharmacological manipulation of the NO system did not cause any significant changes either in the basal firing rate and bursting activity of the dopamine (DA) neurons in the substantia nigra pars compacta (SNc) or in DA release in the striatum. In contrast, the disruption of endogenous NO tone was able to counteract the phasic dopaminergic activation induced by nicotine treatment in both experimental approaches. These results further support the possibility that nicotine acts via a NO mechanism and suggest a possible state-dependent facilitatory control of NO on the nigrostriatal DA pathway. Thus, NO selectively modulates the DA exocytosis associated with increased DA function",
author = "Arcangelo Benigno and Maurizio Casarrubea and Giuseppe Crescimanno and Ennio Esposito and Massimo Pierucci and {Di Matteo}, Vincenzo",
year = "2009",
language = "English",
isbn = "978-1-4419-0339-6",
series = "The BASAL GANGLIA",
pages = "309--321",
booktitle = "The Basal Ganglia IX",

}

TY - CHAP

T1 - Nitric Oxide modulation of the dopaminergic nigrostriatal system: focus on nicotine action.

AU - Benigno, Arcangelo

AU - Casarrubea, Maurizio

AU - Crescimanno, Giuseppe

AU - Esposito, Ennio

AU - Pierucci, Massimo

AU - Di Matteo, Vincenzo

PY - 2009

Y1 - 2009

N2 - Nitric oxide (NO) signalling plays an important role in the integration of information processed by the basal ganglia nuclei. Accordingly, considerable evidence has emerged indicating a role for NO in pathophysiological conditions such as Parkinson’s disease (PD), schizophrenia and drug addiction. To further investigate the NO modulation of dopaminergic function in the basal ganglia circuitry, in this study we used in vivo electrophysiology and microdialysis in freely-moving rats. Pharmacological manipulation of the NO system did not cause any significant changes either in the basal firing rate and bursting activity of the dopamine (DA) neurons in the substantia nigra pars compacta (SNc) or in DA release in the striatum. In contrast, the disruption of endogenous NO tone was able to counteract the phasic dopaminergic activation induced by nicotine treatment in both experimental approaches. These results further support the possibility that nicotine acts via a NO mechanism and suggest a possible state-dependent facilitatory control of NO on the nigrostriatal DA pathway. Thus, NO selectively modulates the DA exocytosis associated with increased DA function

AB - Nitric oxide (NO) signalling plays an important role in the integration of information processed by the basal ganglia nuclei. Accordingly, considerable evidence has emerged indicating a role for NO in pathophysiological conditions such as Parkinson’s disease (PD), schizophrenia and drug addiction. To further investigate the NO modulation of dopaminergic function in the basal ganglia circuitry, in this study we used in vivo electrophysiology and microdialysis in freely-moving rats. Pharmacological manipulation of the NO system did not cause any significant changes either in the basal firing rate and bursting activity of the dopamine (DA) neurons in the substantia nigra pars compacta (SNc) or in DA release in the striatum. In contrast, the disruption of endogenous NO tone was able to counteract the phasic dopaminergic activation induced by nicotine treatment in both experimental approaches. These results further support the possibility that nicotine acts via a NO mechanism and suggest a possible state-dependent facilitatory control of NO on the nigrostriatal DA pathway. Thus, NO selectively modulates the DA exocytosis associated with increased DA function

UR - http://hdl.handle.net/10447/38920

UR - http://www.springer.com/series/5558

M3 - Chapter

SN - 978-1-4419-0339-6

T3 - The BASAL GANGLIA

SP - 309

EP - 321

BT - The Basal Ganglia IX

ER -