TY - CONF
T1 - NiII, and ZnII Schiff Base Complexes: Telomeric G-quadruplex Stabilizers
AU - Martorana, Annamaria
AU - Gentile, Carla
AU - Spinello, Angelo
AU - Almerico, Anna Maria
AU - Lauria, Antonino
AU - Terenzi, Alessio
AU - Barone, Giampaolo
AU - Bonsignore, Riccardo
PY - 2014
Y1 - 2014
N2 - Recently, NiII and ZnII metal complexes of the ligand Salpyrim have been synthesized and characterized. Theiraffinity for wild-type h-Telo G-quadruplex DNA and for calf thymus DNA was investigated by UV absorptionspectroscopy, circular dichroism and viscometry. The data collectively suggest that both complexes bindeffectively to G-quadruplexes by direct end-stacking, stabilizing the oligonucleotide secondary structure. Thetwo complexes are also typical B-DNA intercalators. Remarkably, their binding constants, Kb, with the G4sstructures are about 10 fold higher than those with B-DNA, highlighting the selectivity. Experiments toevaluate the biological activity of the two complexes against MCF7 and HeLa cancer cell lines are currentlyongoing.
AB - Recently, NiII and ZnII metal complexes of the ligand Salpyrim have been synthesized and characterized. Theiraffinity for wild-type h-Telo G-quadruplex DNA and for calf thymus DNA was investigated by UV absorptionspectroscopy, circular dichroism and viscometry. The data collectively suggest that both complexes bindeffectively to G-quadruplexes by direct end-stacking, stabilizing the oligonucleotide secondary structure. Thetwo complexes are also typical B-DNA intercalators. Remarkably, their binding constants, Kb, with the G4sstructures are about 10 fold higher than those with B-DNA, highlighting the selectivity. Experiments toevaluate the biological activity of the two complexes against MCF7 and HeLa cancer cell lines are currentlyongoing.
UR - http://hdl.handle.net/10447/98673
M3 - Other
ER -