Recently, NiII and ZnII metal complexes of the ligand Salpyrim have been synthesized and characterized. Theiraffinity for wild-type h-Telo G-quadruplex DNA and for calf thymus DNA was investigated by UV absorptionspectroscopy, circular dichroism and viscometry. The data collectively suggest that both complexes bindeffectively to G-quadruplexes by direct end-stacking, stabilizing the oligonucleotide secondary structure. Thetwo complexes are also typical B-DNA intercalators. Remarkably, their binding constants, Kb, with the G4sstructures are about 10 fold higher than those with B-DNA, highlighting the selectivity. Experiments toevaluate the biological activity of the two complexes against MCF7 and HeLa cancer cell lines are currentlyongoing.
|Numero di pagine||1|
|Stato di pubblicazione||Published - 2014|