TY - JOUR
T1 - New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
AU - Spano', Virginia
AU - Cirrincione, Girolamo
AU - Parrino, Barbara
AU - Diana, Patrizia
AU - Montalbano, Alessandra
AU - Cusimano, Maria Grazia
AU - Barraja, Paola
AU - Carbone, Anna
AU - Cascioferro, Stella Maria
AU - Schillaci, Domenico
PY - 2018
Y1 - 2018
N2 - New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showing a selectivity against the staphylococcal strains. The most active derivatives elicited IC50 values against Staphylococcus aureus ATCC 25923, ranging from 0.40–2.03 µM. The new compounds showed a typical anti-virulence profile, being able to inhibit the biofilm formation without affecting the microbial growth in the planktonic form.
AB - New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showing a selectivity against the staphylococcal strains. The most active derivatives elicited IC50 values against Staphylococcus aureus ATCC 25923, ranging from 0.40–2.03 µM. The new compounds showed a typical anti-virulence profile, being able to inhibit the biofilm formation without affecting the microbial growth in the planktonic form.
UR - http://hdl.handle.net/10447/350219
M3 - Article
SN - 1660-3397
VL - 16
SP - 1
EP - 15
JO - Marine Drugs
JF - Marine Drugs
ER -