32 Citazioni (Scopus)


New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showing a selectivity against the staphylococcal strains. The most active derivatives elicited IC50 values against Staphylococcus aureus ATCC 25923, ranging from 0.40–2.03 µM. The new compounds showed a typical anti-virulence profile, being able to inhibit the biofilm formation without affecting the microbial growth in the planktonic form.
Lingua originaleEnglish
pagine (da-a)1-15
Numero di pagine15
RivistaMarine Drugs
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

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