New protein clustering of breast cancer tissue proteomics using actin content as a cellularity indicator

Patrizia Cancemi, Antonio Marrazzo, Ida Pucci-Minafra, Salvatore Minafra, Antonio Marrazzo, Gianluca Di Cara, Nadia Ninfa Albanese

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24 Citazioni (Scopus)

Abstract

In the present study, we report the comparative proteome profiles of proteins solubilized from 37 breast cancer surgical tissues, normalized for the actin content. Blood-derived proteins were excluded from the analysis. Among the tumor-derived protein spots, a large proportion (39%) was found present in all patients. These included several glycolytic enzymes, detox and heat shock proteins, members of annexin and S100 protein families, cathepsin D, and two "rare" proteins, DDAH2 involved in the angiogenesis control, and the oncogene PARK7. Other proteins, such as psoriasin, galectin1, cofilin, peroredoxins, SH3L1, and others, showed sporadic presence and high expression level, which suggests their possible role for patient stratification.
Lingua originaleEnglish
pagine (da-a)1412-1418
Numero di pagine7
RivistaJournal of Proteome Research
Volume7
Stato di pubblicazionePublished - 2008

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Chemistry(all)

Cita questo

Cancemi, P., Marrazzo, A., Pucci-Minafra, I., Minafra, S., Marrazzo, A., Di Cara, G., & Albanese, N. N. (2008). New protein clustering of breast cancer tissue proteomics using actin content as a cellularity indicator. Journal of Proteome Research, 7, 1412-1418.