New insights in respiratory impedance in young children after repair of congenital diaphragmatic hernia: a cross-sectional study.

Giuliana Ferrante, Giovanni Corsello, Stefania La Grutta, Maria Rita Di Pace, Velia Malizia, Giovanna Cilluffo, Raffaele L. Dellacà, Stefania La Grutta, Enrico Lombardi, Velia Malizia

Risultato della ricerca: Letter

Abstract

Lung function impairment is common in Congenital Diaphragmatic Hernia (CDH) survivors. The aim of this study was to evaluate, in children who underwent CDH surgical repair, mid and long-term consequences on respiratory impedance, investigating the impact of CDH on both resistance and reactance parameters, as well as bronchodilator response.Forced Oscillation Technique (FOT) parameters were collected from 12 patients (2-11 years). Resistance and reactance values at 8 Hz (Rrs8, Xrs8) and the area under the reactance curve (AX) were measured pre and post-salbutamol. Quantitative variables were compared using Mann-Whitney U test. Differences of categorical variables were evaluated using Fisher exact test. Statistically significant differences between measured and predicted values for Rrs8 (p = 0.04), Xrs8 (p = 0.02) and AX (p = 0.01) were found. When stratifying for age, significant difference between measured and predicted values was observed only in children < 5 years (n = 6) (Rrs8 p = 0.03, Xrs8 p = 0.001, AX p = 0.007). With respect to children 5 years (n = 6), the younger ones showed higher z-scores in Rrs8 (p = 0.015), Xrs8 (p = 0.002) and AX (p = 0.002) values. Since the z-score difference was greater than 0.5, it was considered a difference clinically relevant. No differences in bronchodilator response were recorded.In children with CDH an impairment of respiratory impedance measured by FOT is observed only in children aged less than 5 years.
Lingua originaleEnglish
Numero di pagine6
RivistaTHE ITALIAN JOURNAL OF PEDIATRICS
Stato di pubblicazionePublished - 2019

Fingerprint

Electric Impedance
Cross-Sectional Studies
Bronchodilator Agents
Albuterol
Herniorrhaphy
Nonparametric Statistics
Area Under Curve
Survivors
Congenital Diaphragmatic Hernias
Lung

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cita questo

@article{0c87e9c512bc411bbd3e4e68b329b223,
title = "New insights in respiratory impedance in young children after repair of congenital diaphragmatic hernia: a cross-sectional study.",
abstract = "Lung function impairment is common in Congenital Diaphragmatic Hernia (CDH) survivors. The aim of this study was to evaluate, in children who underwent CDH surgical repair, mid and long-term consequences on respiratory impedance, investigating the impact of CDH on both resistance and reactance parameters, as well as bronchodilator response.Forced Oscillation Technique (FOT) parameters were collected from 12 patients (2-11 years). Resistance and reactance values at 8 Hz (Rrs8, Xrs8) and the area under the reactance curve (AX) were measured pre and post-salbutamol. Quantitative variables were compared using Mann-Whitney U test. Differences of categorical variables were evaluated using Fisher exact test. Statistically significant differences between measured and predicted values for Rrs8 (p = 0.04), Xrs8 (p = 0.02) and AX (p = 0.01) were found. When stratifying for age, significant difference between measured and predicted values was observed only in children < 5 years (n = 6) (Rrs8 p = 0.03, Xrs8 p = 0.001, AX p = 0.007). With respect to children 5 years (n = 6), the younger ones showed higher z-scores in Rrs8 (p = 0.015), Xrs8 (p = 0.002) and AX (p = 0.002) values. Since the z-score difference was greater than 0.5, it was considered a difference clinically relevant. No differences in bronchodilator response were recorded.In children with CDH an impairment of respiratory impedance measured by FOT is observed only in children aged less than 5 years.",
author = "Giuliana Ferrante and Giovanni Corsello and {La Grutta}, Stefania and {Di Pace}, {Maria Rita} and Velia Malizia and Giovanna Cilluffo and Dellac{\`a}, {Raffaele L.} and Grutta, {Stefania La} and Enrico Lombardi and Velia Malizia",
year = "2019",
language = "English",
journal = "THE ITALIAN JOURNAL OF PEDIATRICS",
issn = "1824-7288",

}

TY - JOUR

T1 - New insights in respiratory impedance in young children after repair of congenital diaphragmatic hernia: a cross-sectional study.

AU - Ferrante, Giuliana

AU - Corsello, Giovanni

AU - La Grutta, Stefania

AU - Di Pace, Maria Rita

AU - Malizia, Velia

AU - Cilluffo, Giovanna

AU - Dellacà, Raffaele L.

AU - Grutta, Stefania La

AU - Lombardi, Enrico

AU - Malizia, Velia

PY - 2019

Y1 - 2019

N2 - Lung function impairment is common in Congenital Diaphragmatic Hernia (CDH) survivors. The aim of this study was to evaluate, in children who underwent CDH surgical repair, mid and long-term consequences on respiratory impedance, investigating the impact of CDH on both resistance and reactance parameters, as well as bronchodilator response.Forced Oscillation Technique (FOT) parameters were collected from 12 patients (2-11 years). Resistance and reactance values at 8 Hz (Rrs8, Xrs8) and the area under the reactance curve (AX) were measured pre and post-salbutamol. Quantitative variables were compared using Mann-Whitney U test. Differences of categorical variables were evaluated using Fisher exact test. Statistically significant differences between measured and predicted values for Rrs8 (p = 0.04), Xrs8 (p = 0.02) and AX (p = 0.01) were found. When stratifying for age, significant difference between measured and predicted values was observed only in children < 5 years (n = 6) (Rrs8 p = 0.03, Xrs8 p = 0.001, AX p = 0.007). With respect to children 5 years (n = 6), the younger ones showed higher z-scores in Rrs8 (p = 0.015), Xrs8 (p = 0.002) and AX (p = 0.002) values. Since the z-score difference was greater than 0.5, it was considered a difference clinically relevant. No differences in bronchodilator response were recorded.In children with CDH an impairment of respiratory impedance measured by FOT is observed only in children aged less than 5 years.

AB - Lung function impairment is common in Congenital Diaphragmatic Hernia (CDH) survivors. The aim of this study was to evaluate, in children who underwent CDH surgical repair, mid and long-term consequences on respiratory impedance, investigating the impact of CDH on both resistance and reactance parameters, as well as bronchodilator response.Forced Oscillation Technique (FOT) parameters were collected from 12 patients (2-11 years). Resistance and reactance values at 8 Hz (Rrs8, Xrs8) and the area under the reactance curve (AX) were measured pre and post-salbutamol. Quantitative variables were compared using Mann-Whitney U test. Differences of categorical variables were evaluated using Fisher exact test. Statistically significant differences between measured and predicted values for Rrs8 (p = 0.04), Xrs8 (p = 0.02) and AX (p = 0.01) were found. When stratifying for age, significant difference between measured and predicted values was observed only in children < 5 years (n = 6) (Rrs8 p = 0.03, Xrs8 p = 0.001, AX p = 0.007). With respect to children 5 years (n = 6), the younger ones showed higher z-scores in Rrs8 (p = 0.015), Xrs8 (p = 0.002) and AX (p = 0.002) values. Since the z-score difference was greater than 0.5, it was considered a difference clinically relevant. No differences in bronchodilator response were recorded.In children with CDH an impairment of respiratory impedance measured by FOT is observed only in children aged less than 5 years.

UR - http://hdl.handle.net/10447/363000

M3 - Letter

JO - THE ITALIAN JOURNAL OF PEDIATRICS

JF - THE ITALIAN JOURNAL OF PEDIATRICS

SN - 1824-7288

ER -