Natural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey.

Giuseppe Badalamenti, Antonio Russo, Cinzia Ortega, Francesca Maria Tanca, Davide Ottaviani, Camillo Porta, Matteo Santoni, Calogero Mazzara, Andrea Fontana, Maria Antonietta Satolli, Elena Collovà, Giacomo Carteni, Giuseppe Procopio, Gaetano Lanzetta, Roberto Sabbatini, Saverio Cinieri, Evaristo Maiello, Sergio Bracarda, Stefano Luzi Fedeli, Bruno VincenziNicola Silvestris, Vincenzo Adamo, Alfredo Berruti, Toni Ibrahim, Giuseppe Tonini, Rossana Berardi, Sandro Barni, Daniele Santini, Vladimir Virzì, Alessandra Felici

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37 Citazioni (Scopus)

Abstract

BACKGROUND:Bone metastasis represents an increasing clinical problem in advanced renal cell carcinoma (RCC) as disease-related survival improves. There are few data on the natural history of bone disease in RCC.PATIENTS AND METHODS:Data on clinicopathology, survival, skeletal-related events (SREs), and bone-directed therapies for 398 deceased RCC patients (286 male, 112 female) with evidence of bone metastasis were statistically analyzed.RESULTS:Median time to bone metastasis was 25 months for patients without bone metastasis at diagnosis. Median time to diagnosis of bone metastasis by MSKCC risk was 24 months for good, 5 months for intermediate, and 0 months for poor risk. Median number of SREs/patient was one, and 71% of patients experienced at least one SRE. Median times to first, second, and third SRE were 2, 5, and 12 months, respectively. Median survival was 12 months after bone metastasis diagnosis and 10 months after first SRE. Among 181 patients who received zoledronic acid (ZOL), median time to first SRE was significantly prolonged versus control (n = 186) (3 months vs 1 month for control; P<0.05).CONCLUSIONS:RCC patients with bone metastasis are at continuous risk of SREs, and in this survey ZOL effectively reduced this risk.
Lingua originaleEnglish
Numero di pagine7
RivistaPLoS One
Volume8
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Badalamenti, G., Russo, A., Ortega, C., Tanca, F. M., Ottaviani, D., Porta, C., Santoni, M., Mazzara, C., Fontana, A., Satolli, M. A., Collovà, E., Carteni, G., Procopio, G., Lanzetta, G., Sabbatini, R., Cinieri, S., Maiello, E., Bracarda, S., Fedeli, S. L., ... Felici, A. (2013). Natural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey. PLoS One, 8.