Natural history of Cytomegalovirus infection diagnosed with moderate-severe ulcerative colitis

Valeria Criscuoli, Mario Cottone, Maria Rosa Rizzuto, Luigi Montalbano

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Abstract

AIM: To evaluate the natural history of human cytomegalovirus (HCMV) infection in a series of 28 ulcerative colitis patients in whom the search for HCMV was positive. METHODS: A series of 85 patients with moderate-severe ulcerative colitis flare-up were evaluated for a HCMV search by performing a haematoxylin and eosin stain, immunohistochemical assay and nested polymerase chain reaction on rectal biopsies. Among 85 screened patients (19 of whom were steroid resistant/dependant), 28 were positive for HCMV; after remission the patients were followed up clinically and histologically. RESULTS: Among the 22 patients with complete follow-p, in 8 (36%) patients HCMV-DNA persisted in the intestinal specimens. Among the HCMV positive patients, 4 (50%) experienced at least one moderate-severe flare-up of colitis without evidence of peripheral HCMV. Among the 14 HCMV negative patients, 3 with pouches developed pouchitis and 5 out of 11 (45%) experienced a colitis flare-up. CONCLUSION: Our preliminary results suggest that HCMV may remain in the colon after an acute colitis flare-up despite remission; it seems that the virus is not responsible for the disease relapse. (C) 2011 Baishideng. All rights reserved.
Lingua originaleEnglish
Numero di pagine6
RivistaWorld Journal of Gastroenterology
Volume17
Stato di pubblicazionePublished - 2011

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Cytomegalovirus Infections
Ulcerative Colitis
Cytomegalovirus
Colitis
Pouchitis
Hematoxylin
Eosine Yellowish-(YS)
Colon
Coloring Agents
Steroids
Viruses
Biopsy
Recurrence
Polymerase Chain Reaction
DNA

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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title = "Natural history of Cytomegalovirus infection diagnosed with moderate-severe ulcerative colitis",
abstract = "AIM: To evaluate the natural history of human cytomegalovirus (HCMV) infection in a series of 28 ulcerative colitis patients in whom the search for HCMV was positive. METHODS: A series of 85 patients with moderate-severe ulcerative colitis flare-up were evaluated for a HCMV search by performing a haematoxylin and eosin stain, immunohistochemical assay and nested polymerase chain reaction on rectal biopsies. Among 85 screened patients (19 of whom were steroid resistant/dependant), 28 were positive for HCMV; after remission the patients were followed up clinically and histologically. RESULTS: Among the 22 patients with complete follow-p, in 8 (36{\%}) patients HCMV-DNA persisted in the intestinal specimens. Among the HCMV positive patients, 4 (50{\%}) experienced at least one moderate-severe flare-up of colitis without evidence of peripheral HCMV. Among the 14 HCMV negative patients, 3 with pouches developed pouchitis and 5 out of 11 (45{\%}) experienced a colitis flare-up. CONCLUSION: Our preliminary results suggest that HCMV may remain in the colon after an acute colitis flare-up despite remission; it seems that the virus is not responsible for the disease relapse. (C) 2011 Baishideng. All rights reserved.",
author = "Valeria Criscuoli and Mario Cottone and Rizzuto, {Maria Rosa} and Luigi Montalbano",
year = "2011",
language = "English",
volume = "17",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",

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TY - JOUR

T1 - Natural history of Cytomegalovirus infection diagnosed with moderate-severe ulcerative colitis

AU - Criscuoli, Valeria

AU - Cottone, Mario

AU - Rizzuto, Maria Rosa

AU - Montalbano, Luigi

PY - 2011

Y1 - 2011

N2 - AIM: To evaluate the natural history of human cytomegalovirus (HCMV) infection in a series of 28 ulcerative colitis patients in whom the search for HCMV was positive. METHODS: A series of 85 patients with moderate-severe ulcerative colitis flare-up were evaluated for a HCMV search by performing a haematoxylin and eosin stain, immunohistochemical assay and nested polymerase chain reaction on rectal biopsies. Among 85 screened patients (19 of whom were steroid resistant/dependant), 28 were positive for HCMV; after remission the patients were followed up clinically and histologically. RESULTS: Among the 22 patients with complete follow-p, in 8 (36%) patients HCMV-DNA persisted in the intestinal specimens. Among the HCMV positive patients, 4 (50%) experienced at least one moderate-severe flare-up of colitis without evidence of peripheral HCMV. Among the 14 HCMV negative patients, 3 with pouches developed pouchitis and 5 out of 11 (45%) experienced a colitis flare-up. CONCLUSION: Our preliminary results suggest that HCMV may remain in the colon after an acute colitis flare-up despite remission; it seems that the virus is not responsible for the disease relapse. (C) 2011 Baishideng. All rights reserved.

AB - AIM: To evaluate the natural history of human cytomegalovirus (HCMV) infection in a series of 28 ulcerative colitis patients in whom the search for HCMV was positive. METHODS: A series of 85 patients with moderate-severe ulcerative colitis flare-up were evaluated for a HCMV search by performing a haematoxylin and eosin stain, immunohistochemical assay and nested polymerase chain reaction on rectal biopsies. Among 85 screened patients (19 of whom were steroid resistant/dependant), 28 were positive for HCMV; after remission the patients were followed up clinically and histologically. RESULTS: Among the 22 patients with complete follow-p, in 8 (36%) patients HCMV-DNA persisted in the intestinal specimens. Among the HCMV positive patients, 4 (50%) experienced at least one moderate-severe flare-up of colitis without evidence of peripheral HCMV. Among the 14 HCMV negative patients, 3 with pouches developed pouchitis and 5 out of 11 (45%) experienced a colitis flare-up. CONCLUSION: Our preliminary results suggest that HCMV may remain in the colon after an acute colitis flare-up despite remission; it seems that the virus is not responsible for the disease relapse. (C) 2011 Baishideng. All rights reserved.

UR - http://hdl.handle.net/10447/56021

M3 - Article

VL - 17

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

ER -