Natural history of bone metastasis in colorectal cancer: final results of a large Italian bone metastases study

Giuseppe Badalamenti, Cinzia Ortega, Calipari, Giannicola, Venditti, Latiano, Giuseppe Badalamenti, Petrelli, Masini, Davide Ottaviani, Ottone, Salvatore, Aglietta, Stefano Cascinu, Calogero Mazzara, Vincenzo Catalano, Bertolini, Badalamenti, Fratto, TampelliniCinzia Caroti, Raffaele Addeo, Evaristo Maiello, Bruno Vincenzi, Giordani, Nicola Silvestris, Alfredo Falcone, Toni Ibrahim, Giuseppe Tonini, Rossana Berardi, Sandro Barni, Daniele Santini, Fabbri, Vladimir Virzi

Risultato della ricerca: Articlepeer review

87 Citazioni (Scopus)


Background: Data are limited regarding bone metastases from colorectal cancer (CRC). The objective of this studywas to survey the natural history of bone metastasis in CRC.Patients and methods: This retrospective, multicenter, observational study of 264 patients with CRC involving boneexamined cancer treatments, bone metastases characteristics, skeletal-related event (SRE) type and frequency,zoledronic acid therapy, and disease outcomes.Results: Most patients with bone metastases had pathologic T3/4 disease at CRC diagnosis. The spine was the mostcommon site involved (65%), followed by hip/pelvis (34%), long bones (26%), and other sites (17%). Median time fromCRC diagnosis to bone metastases was 11.00 months; median time to first SRE thereafter was 2.00 months. Radiationand pathologic fractures affected 45% and 10% of patients, respectively; 32% of patients had no reported SREs.Patients survived for a median of 7.00 months after bone metastases diagnosis; SREs did not significantly affect survival.Subgroup analyses revealed that zoledronic acid significantly prolonged median time to first SRE (2.00 months versus1.00 month, respectively, P = 0.009) and produced a trend toward improved overall survival versus no zoledronic acid.Conclusion: This study illustrates the burden of bone metastases from CRC and supports the use of zoledronic acid inthis setting.
Lingua originaleEnglish
pagine (da-a)2072-2077
Numero di pagine6
RivistaAnnals of Oncology
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

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