Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors

Beatrice Belmonte, Walter Arancio, Angelo Leone, Alessandro Gulino, Ada Maria Florena, Angelo Leone, Araz Ahmed, Simita Amayo, Isabelle Miletich, Abdo Jurjus

Risultato della ricerca: Article

Abstract

The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland function during homeostasis through the regulation of electrolyte re-absorption, neural stimulation and/or blood vessel wall contraction/relaxation. We also show abnormal expression of NPRA in the stroma of a subset of human SMGs resected from patients diagnosed with oral squamous cell carcinoma (OSCC) of non-salivary gland origin. This finding warrants further research to investigate a possible correlation between early OSCC invasion and NPRA overexpression.
Lingua originaleEnglish
Numero di pagine11
RivistaJournal of Molecular Histology
Stato di pubblicazionePublished - 2019

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All Science Journal Classification (ASJC) codes

  • Histology
  • Physiology
  • Cell Biology

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