The inclusion of polyphenols into nanoporous materials may significantly improve their application asradical trapping agents for therapeutic purposes. In the present work, nanosponges based on hypercross-linked cyclodextrins and calixarenes (NS1–NS3) were used as carriers of three natural phenolicantioxidants: quercetin (Que), curcumin (Cur) and phenethyl caffeate (Phec). Good w/w loadings, namely7.3% for the Que–NS1 composite, 17.3% for Cur–NS2 and 12.9% for Phec–NS3, were achieved. Therelease kinetics and the inhibition rate constants (kinh) of the reaction with alkylperoxyl radicals (ROO.) in0.1 M phosphate buffer solutions at pH 7.4 were studied and indicated better antioxidant activity ascompared to the phenols alone. The three phenols suffered a dramatic reduction of kinh upon increasingtheir concentration, as a result of their degradation. The inclusion into the nanosponges protected theantioxidants and provided a controlled release in an aqueous medium. Hence, different applications canbe envisaged, in food and pharmaceutical technology fields.
|Numero di pagine||8|
|Stato di pubblicazione||Published - 2020|