Myofibroblasts Are Evidence of Chronic Tissue Microtrauma at the Endometrial-Myometrial Junctional Zone in Uteri With Adenomyosis

Vito Chiantera, Johanna Plendl, Martin Sillem, Mohamed Gamal Ibrahim, Sylvia Mechsner, Vito Chiantera, Jalid Sehouli

Risultato della ricerca: Article

18 Citazioni (Scopus)

Abstract

Adenomyosis (AM) uteri exhibit hyperperistalsis. The latter causes a chronic tissue trauma at the endometrial-myometrial junctional zone (EMJZ). Upon tissue trauma, microdehiscences in the myometrium facilitate the translocation of basal endometrial fragments into the myometrium. There, a metaplasia (mediated by transforming growth factor β1 [TGFβ1] and connective tissue growth factor [CTGF]) occurs and AM lesions develop. The abundance of myofibroblasts in a tissue hallmarks metaplasia and points to a tissue microtrauma.
Lingua originaleEnglish
pagine (da-a)1-9
Numero di pagine9
RivistaReproductive Sciences
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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