Myocardial (123)metaiodobenzylguanidine uptake in genetic Parkinson's disease

Giovanni Savettieri, Marco D'Amelio, Piercostanzo Loizzo, Maurizio Morelli, Fabiana Novellino, Francesca Emanuela Rocca, Antonio Bagnato, Giuseppe Nicoletti, Innocenza Claudia Cirò Candiano, Donatella Civitelli, Ferdinanda Annesi, Grazia Annesi, Letterio Morgante, Alfredo Petrone, Mario Zappia, Aldo Quattrone, Francesca Condino, Patrizia Tarantino

Risultato della ricerca: Article

46 Citazioni (Scopus)

Abstract

Myocardial 123Metaiodobenzylguanidine (MIBG)enables the assessment of postganglionic sympathetic cardiac innervation. MIBG uptake is decreased in nearly all patients with Parkinson’s disease (PD). Our objective was to evaluate MIBG uptake in patients with genetic PD. We investigated MIBG uptake in 14 patients with PD associated with mutations in different genes (Parkin, DJ-1, PINK1, and leucine-rich repeat kinase 2 -LRRK2), in 15 patients with idiopathic PD, and 10 control subjects. The myocardial MIGB uptake was preserved in 3 of the 4 Parkin-associated Parkinsonisms, in 1 of the2 patients with DJ-1 mutations, in 1 of the 2 brothers with PINK1 mutations, in 3 of the 6 unrelated patients with Gly2019Ser mutation in the LRRK2 gene, whereas it was impaired in all patients with idiopathic PD. MIBG was preservedin all control subjects. Our study shows that myocardial MIGB uptake was normal in 8 of 14 patients with genetic PD, suggesting that cardiac sympathetic denervation occurs lessfrequently in genetic PD than in idiopathic PD. Our findings also demonstrate that MIGB uptake has a heterogeneous pattern in genetic PD, because it was differently impaired inpatients with different mutations in the same gene or with the same gene mutation.
Lingua originaleEnglish
pagine (da-a)21-27
Numero di pagine7
RivistaMovement Disorders
Volume23
Stato di pubblicazionePublished - 2008

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cita questo

Savettieri, G., D'Amelio, M., Loizzo, P., Morelli, M., Novellino, F., Rocca, F. E., Bagnato, A., Nicoletti, G., Candiano, I. C. C., Civitelli, D., Annesi, F., Annesi, G., Morgante, L., Petrone, A., Zappia, M., Quattrone, A., Condino, F., & Tarantino, P. (2008). Myocardial (123)metaiodobenzylguanidine uptake in genetic Parkinson's disease. Movement Disorders, 23, 21-27.