TY - JOUR
T1 - Myocardial (123)metaiodobenzylguanidine uptake in genetic Parkinson's disease
AU - D'Amelio, Marco
AU - Savettieri, Giovanni
AU - Loizzo, Piercostanzo
AU - Morelli, Maurizio
AU - Novellino, Fabiana
AU - Rocca, Francesca Emanuela
AU - Bagnato, Antonio
AU - Nicoletti, Giuseppe
AU - Rocca, Francesca Emanuela
AU - Candiano, Innocenza Claudia Cirò
AU - Civitelli, Donatella
AU - Annesi, Ferdinanda
AU - Annesi, Grazia
AU - Morgante, Letterio
AU - Petrone, Alfredo
AU - Zappia, Mario
AU - Quattrone, Aldo
AU - Condino, Francesca
AU - Tarantino, Patrizia
PY - 2008
Y1 - 2008
N2 - Myocardial 123Metaiodobenzylguanidine (MIBG)enables the assessment of postganglionic sympathetic cardiac innervation. MIBG uptake is decreased in nearly all patients with Parkinson’s disease (PD). Our objective was to evaluate MIBG uptake in patients with genetic PD. We investigated MIBG uptake in 14 patients with PD associated with mutations in different genes (Parkin, DJ-1, PINK1, and leucine-rich repeat kinase 2 -LRRK2), in 15 patients with idiopathic PD, and 10 control subjects. The myocardial MIGB uptake was preserved in 3 of the 4 Parkin-associated Parkinsonisms, in 1 of the2 patients with DJ-1 mutations, in 1 of the 2 brothers with PINK1 mutations, in 3 of the 6 unrelated patients with Gly2019Ser mutation in the LRRK2 gene, whereas it was impaired in all patients with idiopathic PD. MIBG was preservedin all control subjects. Our study shows that myocardial MIGB uptake was normal in 8 of 14 patients with genetic PD, suggesting that cardiac sympathetic denervation occurs lessfrequently in genetic PD than in idiopathic PD. Our findings also demonstrate that MIGB uptake has a heterogeneous pattern in genetic PD, because it was differently impaired inpatients with different mutations in the same gene or with the same gene mutation.
AB - Myocardial 123Metaiodobenzylguanidine (MIBG)enables the assessment of postganglionic sympathetic cardiac innervation. MIBG uptake is decreased in nearly all patients with Parkinson’s disease (PD). Our objective was to evaluate MIBG uptake in patients with genetic PD. We investigated MIBG uptake in 14 patients with PD associated with mutations in different genes (Parkin, DJ-1, PINK1, and leucine-rich repeat kinase 2 -LRRK2), in 15 patients with idiopathic PD, and 10 control subjects. The myocardial MIGB uptake was preserved in 3 of the 4 Parkin-associated Parkinsonisms, in 1 of the2 patients with DJ-1 mutations, in 1 of the 2 brothers with PINK1 mutations, in 3 of the 6 unrelated patients with Gly2019Ser mutation in the LRRK2 gene, whereas it was impaired in all patients with idiopathic PD. MIBG was preservedin all control subjects. Our study shows that myocardial MIGB uptake was normal in 8 of 14 patients with genetic PD, suggesting that cardiac sympathetic denervation occurs lessfrequently in genetic PD than in idiopathic PD. Our findings also demonstrate that MIGB uptake has a heterogeneous pattern in genetic PD, because it was differently impaired inpatients with different mutations in the same gene or with the same gene mutation.
UR - http://hdl.handle.net/10447/25563
M3 - Article
VL - 23
SP - 21
EP - 27
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
ER -