Myeloid cell heterogeneity in lung cancer: implication for immunotherapy

Claudio Tripodo, Marina Chiara Garassino, Roberto Ferrara, Sabina Sangaletti, Claudio Tripodo, Mario Paolo Colombo

Risultato della ricerca: Articlepeer review

Abstract

Lung is a specialized tissue where metastases from primary lung tumors takeoff and those originating from extra-pulmonary sites land. One commonality characterizing these processes is the supportive role exerted by myeloid cells, particularly neutrophils, whose recruitment is facilitated in this tissue microenvironment. Indeed, neutrophils have important part in the pathophysiology of this organ and the key mechanisms regulating neutrophil expansion and recruitment during infection can be co-opted by tumor cells to promote growth and metastasis. Although neutrophils dominate the myeloid landscape of lung cancer other populations including macrophages, dendritic cells, mast cells, basophils and eosinophils contribute to the complexity of lung cancer TME. In this review, we discuss the origin and significance of myeloid cells heterogeneity in lung cancer, which translates not only in a different frequency of immune populations but it encompasses state of activation, morphology, localization and mutual interactions. The relevance of such heterogeneity is considered in the context of tumor growth and response to immunotherapy.
Lingua originaleEnglish
Numero di pagine10
RivistaCANCER IMMUNOLOGY, IMMUNOTHERAPY
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2723???
  • ???subjectarea.asjc.2400.2403???
  • ???subjectarea.asjc.2700.2730???
  • ???subjectarea.asjc.1300.1306???

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