Multisciplinary management of patients with liver metastasis from colorectal cancer

Francesco Passiglia, Konstantinos Papadimitriou, Antonio Russo, Giuseppe Bronte, Marc Peeters, Konstantinos Papadimitriou, Francesco Passiglia, Andreia Coelho, Christian Rolfo, Thiery Chapelle, Kathleen De Greef, Christian Diego Rolfo

Risultato della ricerca: Articlepeer review

44 Citazioni (Scopus)

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related death. Surgery, radiotherapy and chemotherapy have been till now the main therapeutic strategies for disease control and improvement of the overall survival. Twenty-five per cent (25%) of CRC patients have clinically detectable liver metastases at the initial diagnosis and approximately 50% develop liver metastases during their disease course. Twentythirty per cent (20%-30%) are CRC patients with metastases confined to the liver. Some years ago various studies showed a curative potential for liver metastases resection. For this reason some authors proposed the conversion of unresectable liver metastases to resectable to achieve cure. Since those results were published, a lot of regimens have been studied for resectability potential. Better results could be obtained by the combination of chemotherapy with targeted drugs, such as anti-VEGF and anti-EGFR monoclonal antibodies. However an accurate selection for patients to treat with these regimens and to operate for liver metastases is mandatory to reduce the risk of complications. A multidisciplinary team approach represents the best way for a proper patient management. The team needs to include surgeons, oncologists, diagnostic and interventional radiologists with expertise in hepatobiliary disease, molecular pathologists, and clinical nurse specialists. This review summarizes the most important findings on surgery and systemic treatment of CRC-related liver metastases.
Lingua originaleEnglish
pagine (da-a)7215-7225
Numero di pagine11
RivistaWorld Journal of Gastroenterology
Volume22
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

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