Multiplicity and history have a detrimental effect on survival in patients with T1G3 bladder tumors selected for conservative treatment.

Vincenzo Serretta, Rosalinda Allegro, Darvinio Melloni, Nino Dispensa, Rosalinda Allegro, Antonina Ruggirello, Rosalinda Allegro, Nino Dispensa, Darvinio Melloni, Vincenzo Serretta

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8 Citazioni (Scopus)


Purpose: In the absence of Tis tumor we assessed whether history and multiplicity have a detrimental effect on conservativetreatment in carefully selected patients with T1G3 bladder carcinoma.Materials and Methods: Between January 1976 and December 1999, 165 select patients with T1G3 bladder tumors wereconservatively treated with transurethral resection plus adjuvant intravesical therapy. Patients with concomitant orprevious Tis, previous T1G3, tumor size greater than 3 cm and more than 3 lesions were excluded from analysis. Repeattransurethral resection was not routinely performed. However, cytology had to be negative for atypia before the start ofadjuvant intravesical therapy.Results: Recurrence-free survival at 1, 3 and 5 years was 71.8%, 55.6% and 45%, respectively. Of the cases 14 (8.4%)progressed with a median progression-free survival of 149 months. A total of 23 patients (14%) died. The 5-year recurrencefreesurvival rate was 52%, 34% and 15% in cases of single and/or primary, multiple and recurrent tumors, respectively.Median overall survival was 144 months. The 5-year disease-free overall survival rate was 85%, 83%, 79% and 69% in casesof primary, single, multiple and recurrent tumors, respectively. An intact bladder was maintained in 137 patients (83%) witha mean disease-free overall survival of 102.7 months. Patients with recurrent and/or multiple T1G3 tumors showed worsesurvival (p 0.0021 and 0.0142, respectively).Conclusions: History and multiplicity are relevant predictors of survival even in highly selected patients with TIG3 bladdertumors that are conservatively treated.Key Words: carcinoma, transitional cell; survival; chemotherapy, adjuvant; neoplasms, multiple primary; recurrence
Lingua originaleEnglish
pagine (da-a)886-891
Numero di pagine6
Stato di pubblicazionePublished - 2008

All Science Journal Classification (ASJC) codes

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