Multiple sclerosis: High prevalence of the ‘central vein’ sign in white matter lesions on susceptibility-weighted images

Massimo Midiri, Gianvincenzo Sparacia, Francesco Agnello, Martina Sciortino, Angelo Gambino

Risultato della ricerca: Articlepeer review

15 Citazioni (Scopus)

Abstract

Purpose: The aim of this study was to determine the occurrence and distribution of the ‘central vein’ sign in white matterlesions on susceptibility-weighted magnetic resonance images in patients with multiple sclerosis (MS) and cerebral smallvessel disease (CSVD).Materials and methods: T2-weighted and fluid-attenuated inversion recovery magnetic resonance images of 19 MS patientsand 19 patients affected by CSVD were analysed for the presence and localisation of focal hyperintense white matter lesions.Lesions were subdivided into periventricular or non-periventricular (juxtacortical, subcortical, deep white matter andcerebellar) distributed. The number and localisation of lesions presenting with the central vein sign were recorded andcompared between MS and CSVD lesions.Results: A total of 313 MS patients and 75 CSVD lesions were identified on T2-weighted and fluid-attenuated inversionrecovery magnetic resonance images. The central vein sign was found in 128 MS lesions (40.9%), and the majority of them(71/128, 55.5%) had a periventricular distribution. The central vein sign was found in 22 out of 75 (29.3%) CSVD lesions, andperiventricular distribution was seen in six out of 22 (27.2%) CSVD lesions. The difference in the proportion of white matterhyperintense lesions that presented with the central vein sign on susceptibility-weighted images in patients with MS andCSVD was statistically different, and a significantly higher number of MS patients presented with lesions with the centralvein sign compared to CSVD patients.Conclusion: The presence of the central vein sign on susceptibility-weighted images for MS lesions improves the understanding of the periventricular distribution of MS lesions and could contribute as adjunctive diagnostic criteria for MSdisease.
Lingua originaleEnglish
pagine (da-a)356-361
Numero di pagine6
RivistaTHE NEURORADIOLOGY JOURNAL
Volume31
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2728???

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