Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis

Toscani, D.; Giuliani, N.

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8 Citazioni (Scopus)

Abstract

Multiple myeloma (MM) is a clonal plasma cell malignancy associated with osteolytic bone disease. Recently, the role of MM-derived exosomes in the osteoclastogenesis has been demonstrated although the underlying mechanism is still unknown. Since exosomes-derived epidermal growth factor receptor ligands (EGFR) are involved in tumor-associated osteolysis, we hypothesize that the EGFR ligand amphiregulin (AREG) can be delivered by MM-derived exosomes and participate in MM-induced osteoclastogenesis.
Lingua originaleEnglish
pagine (da-a)2-00
Numero di pagine15
RivistaJOURNAL OF HEMATOLOGY & ONCOLOGY
Volume12
Stato di pubblicazionePublished - 2019

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Exosomes
Multiple Myeloma
Epidermal Growth Factor
Osteogenesis
Bone and Bones
Ligands
Epidermal Growth Factor Receptor
Osteolysis
Bone Diseases
Plasma Cells
Neoplasms
Amphiregulin

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title = "Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis",
abstract = "Multiple myeloma (MM) is a clonal plasma cell malignancy associated with osteolytic bone disease. Recently, the role of MM-derived exosomes in the osteoclastogenesis has been demonstrated although the underlying mechanism is still unknown. Since exosomes-derived epidermal growth factor receptor ligands (EGFR) are involved in tumor-associated osteolysis, we hypothesize that the EGFR ligand amphiregulin (AREG) can be delivered by MM-derived exosomes and participate in MM-induced osteoclastogenesis.",
author = "{Toscani, D.; Giuliani, N.} and Riccardo Alessandro and Samuele Raccosta and Laura Saieva and Stefania Raimondo and Mauro Manno and Marzia Pucci and Emanuela Vicario",
year = "2019",
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journal = "Journal of Hematology and Oncology",
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T1 - Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis

AU - Toscani, D.; Giuliani, N.

AU - Alessandro, Riccardo

AU - Raccosta, Samuele

AU - Saieva, Laura

AU - Raimondo, Stefania

AU - Manno, Mauro

AU - Pucci, Marzia

AU - Vicario, Emanuela

PY - 2019

Y1 - 2019

N2 - Multiple myeloma (MM) is a clonal plasma cell malignancy associated with osteolytic bone disease. Recently, the role of MM-derived exosomes in the osteoclastogenesis has been demonstrated although the underlying mechanism is still unknown. Since exosomes-derived epidermal growth factor receptor ligands (EGFR) are involved in tumor-associated osteolysis, we hypothesize that the EGFR ligand amphiregulin (AREG) can be delivered by MM-derived exosomes and participate in MM-induced osteoclastogenesis.

AB - Multiple myeloma (MM) is a clonal plasma cell malignancy associated with osteolytic bone disease. Recently, the role of MM-derived exosomes in the osteoclastogenesis has been demonstrated although the underlying mechanism is still unknown. Since exosomes-derived epidermal growth factor receptor ligands (EGFR) are involved in tumor-associated osteolysis, we hypothesize that the EGFR ligand amphiregulin (AREG) can be delivered by MM-derived exosomes and participate in MM-induced osteoclastogenesis.

UR - http://hdl.handle.net/10447/336561

M3 - Article

VL - 12

SP - 2

EP - 0

JO - Journal of Hematology and Oncology

JF - Journal of Hematology and Oncology

SN - 1756-8722

ER -