MULTIOMICS ANALYSIS OF S100 PROTEINS IN BREAST CANCER

Risultato della ricerca: Other

Abstract

The S100 gene family is the largest subfamily of calcium bindingproteins of EF-hand type, expressed in tissue and cell-specificmanner. S100 proteins act as intracellular regulators and asextracellular signaling. Within cells, S100 have been involved inthe regulation of proliferation, differentiation, apoptosis, energymetabolism, inflammation, migration and invasion via interactionswith a variety of target proteins. Extracellular S100 proteinsact in an autocrine and paracrine manner through the activationof surface receptors that regulate cell proliferation, differentiation,survival and migration. More recently, there isgrowing interest in the S100 proteins and their relationship withdifferent cancers because of their involvement in a variety ofbiological events closely related to tumorigenesis and cancerprogression1. However, the occurrence, the role and the possiblecoordination of this group of proteins in breast cancer is stillpoorly known. We previously describe a large-scale proteomicinvestigation performed on breast cancer patients for thescreening of multiple forms of S100 proteins2,3. Our results haveshown that the majority of S100 proteins are preferentiallyexpressed in the tumor mass compared with the normal adjacenttissue and that some S100 protein members were ubiquitouslyexpressed in almost all patients, while others appeared moresporadic among the same group of patients. More interestingly,patients which developed distant metastases showed a generaltendency of higher S100 protein expression, compared to thedisease-free group. Present study was aimed to assess the geneexpression levels of the S100 protein family members utilizing abreast cancer dataset generated on Affymetrix microarraystechnologies4. GOBO (Gene expression-based Outcome forBreast cancer Online) is a user-friendly online tool that allows,also, the identification of co-expressed genes and associationwith outcome in an 1881 breast cancer samples. Other importantassociation with breast cancer outome was carried out byKaplan Meir-plotter database5. Integrating results obtained byproteomic and trascriptomic analysis of S100 proteins highlighttheir important involvement in breast cancer progression, andsupport the idea that S100 proteins are important prognosticfactors, related to survival period of tumor patients. However,the specific mechanisms by which S100 proteins affect progressionof breast require further study.
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2015

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