Multifunctional Carrier Based on Halloysite/Laponite Hybrid Hydrogel for Kartogenin Delivery

Marina Massaro, Carla Rizzo, Giuseppa Biddeci, Francesca D'Anna, Giuseppe Cavallaro, Angelo Ferrante, Giuseppe Lazzara, Serena Riela, Gaetano Spinelli, Luca Arista, Giuseppa Biddeci, Thomas Ullrich, Francesco Di Blasi

Risultato della ricerca: Articlepeer review

12 Citazioni (Scopus)

Abstract

A novel carrier system based on halloysite nanotubes (HNT), for the potential intraarticular delivery of kartogenin (KGN) by means laponite (Lap) hydrogel (HNT/KGN/Lap), is developed. The drug was first loaded into HNT, and the hybrid composite obtained was used as filler for laponite hydrogel. Both the filler and the hydrogel were thoroughly investigated by several techniques and the hydrogel morphology was imaged by transmission electron microscopy. Furthermore, the gelating ability of laponite in the presence of the filler and the rheological properties of the hybrid hydrogel were also investigated. The kinetic release of kartogenin from HNT and HNT/Lap hybrid hydrogel was studied both in physiological conditions and in ex vivo synovial fluid. In the last case, the kinetic results highlighted that HNT carrier can effectively release KGN in a sustained manner for at least 38 days. Finally, a preliminary biological assays showed that the HNT/KGN/Lap hybrid hydrogel did not exhibit any cytotoxic effect.
Lingua originaleEnglish
pagine (da-a)419-424
Numero di pagine6
RivistaACS Medicinal Chemistry Letters
Volume10
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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