Abstract

Multicavity halloysite nanotube materials were employed as simultaneous carriers for two different natural drugs, silibinin and quercetin, at 6.1% and 2.2% drug loadings, respectively. The materials were obtained by grafting functionalized amphiphilic cyclodextrin onto the HNT external surface. The new materials were characterized by FT-IR spectroscopy, SEM, thermogravimetry, turbidimetry, dynamic light scattering and ζ-potential techniques. The interaction of the two molecules with the carrier was studied by HPLC measurements and fluorescence spectroscopy, respectively. The release of the drugs from HNT-amphiphilic cyclodextrin, at two different pH values, was also investigated by means of UV-vis spectroscopy. Biological assays showed that the new complex exhibits anti-proliferative activity against human anaplastic thyroid cancer cell lines 8505C. Furthermore, fluorescence microscopy was used to evaluate whether the carrier was uptaken into 8505C thyroid cancer cell lines. The successful results revealed that the synthesized multicavity system is a material of suitable size to transport drugs into living cells.
Lingua originaleEnglish
pagine (da-a)4074-4081
Numero di pagine8
RivistaJOURNAL OF MATERIALS CHEMISTRY. B
Volume3
Stato di pubblicazionePublished - 2015

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Cyclodextrins
Cells
Pharmaceutical Preparations
Fluorescence microscopy
Quercetin
Fluorescence spectroscopy
Dynamic light scattering
Ultraviolet spectroscopy
Nanotubes
Thermogravimetric analysis
Infrared spectroscopy
Assays
Scanning electron microscopy
Molecules
clay

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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@article{172293f6b3e94641ba5e7eb1ea6bb2d4,
title = "Multicavity halloysite-amphiphilic cyclodextrin hybrids for co-delivery of natural drugs into thyroid cancer cells",
abstract = "Multicavity halloysite nanotube materials were employed as simultaneous carriers for two different natural drugs, silibinin and quercetin, at 6.1{\%} and 2.2{\%} drug loadings, respectively. The materials were obtained by grafting functionalized amphiphilic cyclodextrin onto the HNT external surface. The new materials were characterized by FT-IR spectroscopy, SEM, thermogravimetry, turbidimetry, dynamic light scattering and ζ-potential techniques. The interaction of the two molecules with the carrier was studied by HPLC measurements and fluorescence spectroscopy, respectively. The release of the drugs from HNT-amphiphilic cyclodextrin, at two different pH values, was also investigated by means of UV-vis spectroscopy. Biological assays showed that the new complex exhibits anti-proliferative activity against human anaplastic thyroid cancer cell lines 8505C. Furthermore, fluorescence microscopy was used to evaluate whether the carrier was uptaken into 8505C thyroid cancer cell lines. The successful results revealed that the synthesized multicavity system is a material of suitable size to transport drugs into living cells.",
author = "Serena Riela and Carla Giordano and Giuseppe Cavallaro and Renato Noto and Giuseppe Lazzara and Marina Massaro and Concetta Baiamonte and Giuseppe Pizzolanti and Colletti, {Carmelo Giuseppe} and Stefana Milioto",
year = "2015",
language = "English",
volume = "3",
pages = "4074--4081",
journal = "JOURNAL OF MATERIALS CHEMISTRY. B",
issn = "2050-7518",

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TY - JOUR

T1 - Multicavity halloysite-amphiphilic cyclodextrin hybrids for co-delivery of natural drugs into thyroid cancer cells

AU - Riela, Serena

AU - Giordano, Carla

AU - Cavallaro, Giuseppe

AU - Noto, Renato

AU - Lazzara, Giuseppe

AU - Massaro, Marina

AU - Baiamonte, Concetta

AU - Pizzolanti, Giuseppe

AU - Colletti, Carmelo Giuseppe

AU - Milioto, Stefana

PY - 2015

Y1 - 2015

N2 - Multicavity halloysite nanotube materials were employed as simultaneous carriers for two different natural drugs, silibinin and quercetin, at 6.1% and 2.2% drug loadings, respectively. The materials were obtained by grafting functionalized amphiphilic cyclodextrin onto the HNT external surface. The new materials were characterized by FT-IR spectroscopy, SEM, thermogravimetry, turbidimetry, dynamic light scattering and ζ-potential techniques. The interaction of the two molecules with the carrier was studied by HPLC measurements and fluorescence spectroscopy, respectively. The release of the drugs from HNT-amphiphilic cyclodextrin, at two different pH values, was also investigated by means of UV-vis spectroscopy. Biological assays showed that the new complex exhibits anti-proliferative activity against human anaplastic thyroid cancer cell lines 8505C. Furthermore, fluorescence microscopy was used to evaluate whether the carrier was uptaken into 8505C thyroid cancer cell lines. The successful results revealed that the synthesized multicavity system is a material of suitable size to transport drugs into living cells.

AB - Multicavity halloysite nanotube materials were employed as simultaneous carriers for two different natural drugs, silibinin and quercetin, at 6.1% and 2.2% drug loadings, respectively. The materials were obtained by grafting functionalized amphiphilic cyclodextrin onto the HNT external surface. The new materials were characterized by FT-IR spectroscopy, SEM, thermogravimetry, turbidimetry, dynamic light scattering and ζ-potential techniques. The interaction of the two molecules with the carrier was studied by HPLC measurements and fluorescence spectroscopy, respectively. The release of the drugs from HNT-amphiphilic cyclodextrin, at two different pH values, was also investigated by means of UV-vis spectroscopy. Biological assays showed that the new complex exhibits anti-proliferative activity against human anaplastic thyroid cancer cell lines 8505C. Furthermore, fluorescence microscopy was used to evaluate whether the carrier was uptaken into 8505C thyroid cancer cell lines. The successful results revealed that the synthesized multicavity system is a material of suitable size to transport drugs into living cells.

UR - http://hdl.handle.net/10447/145353

UR - http://pubs.rsc.org/en/journals/journalissues/tb

M3 - Article

VL - 3

SP - 4074

EP - 4081

JO - JOURNAL OF MATERIALS CHEMISTRY. B

JF - JOURNAL OF MATERIALS CHEMISTRY. B

SN - 2050-7518

ER -