Multi-omics of Pseudoalteromonas haloplanktis TAC125: a quest for antimicrobial metabolic pathways

Risultato della ricerca: Otherpeer review


BackgroundsThe Antarctic strain Pseudoalteromonas haloplanktis TAC125 is one of the model organisms of cold-adapted bacteria and is currently exploited as a new alternative expression host for numerous biotechnological applications. Interestingly, this bacterium has been reported to be able to inhibit the growth of Burkholderia cepacia complex (Bcc) strains, opportunistic pathogens responsible for the infection of immune-compromised patients. Most likely, this occurs through the synthesis of several different compounds, including Volatile Organic Compounds (VOCs), whose nature andcharacteristics are currently mostly unknown. ObjectivesTo obtain a complete picture of cellular processes differentially regulated and associated with the capability of inhibiting Bcc growth.MethodsTranscriptomic, proteomic and metabolomic experiments were carried out on P. haloplanktis TAC125 grown using two different cultivation media in which the strain is able to inhibit or not Bcc growth. ConclusionsBcc growth inhibition capability is deeply linked to the medium used to cultivate P. haloplanktis TAC125. Therefore, multi-omic data integration was used in order to explain the emergence of P. haloplanktis TAC125 phenotypes and, specifically, of cellular functional states associated to capabilityof inhibiting Bcc growth. In perspectives, the design of more focused strategies for a rational biotechnological exploitation of this strain will be boosted by the approach used and the results obtained in this work.
Lingua originaleEnglish
Numero di pagine0
Stato di pubblicazionePublished - 2017


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