TY - JOUR
T1 - Multi-objective optimization of nitinol stent design
AU - Zingales, Massimiliano
AU - Conti, null
AU - Alaimo, Gianluca
AU - Zingales, Massimiliano
AU - Auricchio, null
PY - 2017
Y1 - 2017
N2 - Nitinol stents continuously experience loadings due to pulsatile pressure, thus a given stent design should possess an adequate fatigue strength and, at the same time, it should guarantee a sufficient vessel scaffolding. The present study proposes an optimization framework aiming at increasing the fatigue life reducing the maximum strut strain along the structure through a local modification of the strut profile.The adopted computational framework relies on nonlinear structural finite element analysis combined with a Multi Objective Genetic Algorithm, based on Kriging response surfaces. In particular, such an approach is used to investigate the design optimization of planar stent cell.The results of the strut profile optimization confirm the key role of a tapered strut design to enhance the stent fatigue strength, suggesting that it is possible to achieve a marked improvement of both the fatigue safety factor and the scaffolding capability simultaneously. The present study underlines the value of advanced engineering tools to optimize the design of medical devices.
AB - Nitinol stents continuously experience loadings due to pulsatile pressure, thus a given stent design should possess an adequate fatigue strength and, at the same time, it should guarantee a sufficient vessel scaffolding. The present study proposes an optimization framework aiming at increasing the fatigue life reducing the maximum strut strain along the structure through a local modification of the strut profile.The adopted computational framework relies on nonlinear structural finite element analysis combined with a Multi Objective Genetic Algorithm, based on Kriging response surfaces. In particular, such an approach is used to investigate the design optimization of planar stent cell.The results of the strut profile optimization confirm the key role of a tapered strut design to enhance the stent fatigue strength, suggesting that it is possible to achieve a marked improvement of both the fatigue safety factor and the scaffolding capability simultaneously. The present study underlines the value of advanced engineering tools to optimize the design of medical devices.
KW - Biomedical Engineering
KW - Biophysics
KW - Fatigue
KW - Multi-objective optimization
KW - Nitinol
KW - Stent
KW - Structural finite element analysis
KW - Tapered strut
KW - Biomedical Engineering
KW - Biophysics
KW - Fatigue
KW - Multi-objective optimization
KW - Nitinol
KW - Stent
KW - Structural finite element analysis
KW - Tapered strut
UR - http://hdl.handle.net/10447/260220
UR - http://www.elsevier.com/locate/medengphy
M3 - Article
VL - 47
SP - 13
EP - 24
JO - MEDICAL ENGINEERING & PHYSICS
JF - MEDICAL ENGINEERING & PHYSICS
SN - 1350-4533
ER -