Mullarian-inhibiting substance reflects ovarian findings in women with polycystic ovary syndrome better than does inhibin-B

Enrico Carmina, Rogerio A. Lobo, Micheline C. Chu, Jeff Wang

Risultato della ricerca: Articlepeer review

27 Citazioni (Scopus)


Objective: To investigate Müllerian-inhibiting substance (MIS) levels in women with polycystic ovary syndrome(PCOS), as well as relationships to ovarian morphology, levels of inhibin B, and other reproductive hormones.Design: Prospective clinical study.Setting: Academic endocrinology centers in Palermo, Italy and New York.Patient(s): Forty-six women with PCOS, recruited on the basis of the classic criteria of chronic anovulation andhyperandrogenism, and 25 age-matched ovulatory controls.Intervention(s): Fasting blood was obtained in all subjects in the early follicular phase (days 5–6) afterspontaneous or induced menses (in PCOS), and transvaginal ultrasounds were performed.Main Outcome Measure(s): Assessment of values for luteinizing hormone (LH), testosterone (T), androstenedione(A), estradiol (E2), inhibin B, MIS, fasting insulin, and the calculated quantitative sensitivity check index(QUICKI), as well as assessments of ovarian volume and blood flow.Result(s): Women with PCOS had higher LH, T, and A; higher insulin and lower QUICKI; and higher ovarianvolume and lower pulsatility index. Inhibin B concentrations were statistically significantly higher in PCOSpatients (70 8.0 vs. 40 3.4 pg/mL), as was MIS (6.7 0.9 vs. 4.6 0.5 ng/mL). Inhibin B had a statisticallysignificant direct correlation with levels of MIS (r 0.351). However, MIS, but not inhibin B, had a statisticallysignificant positive correlation with ovarian size (r 0.350); the reproductive hormones LH, T, A, and E2; andinsulin (r 0.249), independent of body mass index. Women with PCOS with the highest levels of MIS hadhigher ovarian volumes and values of LH, T, A, and insulin.Conclusion(s): Measurements of MIS reflect ovarian findings in PCOS better than levels of inhibin B and aremore frequently elevated. However, MIS lacks sensitivity for use as a diagnostic tool in PCOS. (Fertil Steril2005;84:1685–8. ©2005 by American Society for Reproductive Medicine.)
Lingua originaleEnglish
pagine (da-a)1685-1688
Numero di pagine4
RivistaFertility and Sterility
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2729???


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