Movements execution in amnestic mild cognitive impairment and Alzheimer's disease.

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21 Citazioni (Scopus)

Abstract

We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and {early} Alzheimer's Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunction in early AD could represent the transition from aMCI to AD.
Lingua originaleEnglish
pagine (da-a)135-142
Numero di pagine8
RivistaDefault journal
Volume18
Stato di pubblicazionePublished - 2007

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Alzheimer Disease
Memory Disorders
Cognitive Dysfunction
Biomechanical Phenomena

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Clinical Neurology

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title = "Movements execution in amnestic mild cognitive impairment and Alzheimer's disease.",
abstract = "We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and {early} Alzheimer's Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunction in early AD could represent the transition from aMCI to AD.",
author = "Cecilia Camarda and Rosolino Camarda and Roberto Monastero and Lawrence Camarda and Massimo Gangitano and Carlo Caltagirone and Carmela Pipia",
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AU - Camarda, Cecilia

AU - Camarda, Rosolino

AU - Monastero, Roberto

AU - Camarda, Lawrence

AU - Gangitano, Massimo

AU - Caltagirone, Carlo

AU - Pipia, Carmela

PY - 2007

Y1 - 2007

N2 - We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and {early} Alzheimer's Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunction in early AD could represent the transition from aMCI to AD.

AB - We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and {early} Alzheimer's Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunction in early AD could represent the transition from aMCI to AD.

UR - http://hdl.handle.net/10447/12643

M3 - Article

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SP - 135

EP - 142

JO - Default journal

JF - Default journal

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