Mouse models of multiple myeloma: Technologic platforms and perspectives

Cirino Botta, Cirino Botta, Marco Rossi, Rosa Daniela Grembiale, Mariamena Arbitrio, Pierfrancesco Tassone, Pierosandro Tagliaferri

Risultato della ricerca: Articlepeer review

13 Citazioni (Scopus)

Abstract

Murine models of human multiple myeloma (MM) are key tools for the study of disease biology as well as for investigation and selection of novel candidate therapeutics for clinical translation. In the last years, a variety of pre-clinical models have been generated to recapitulate a wide spectrum of biological features of MM. These systems range from spontaneous or transgenic models of murine MM, to subcutaneous or orthothopic xenografts of human MM cell lines in immune compromised animals, to platform allowing the engraftment of primary/bone marrowdependent MM cells within a human bone marrow milieu to fully recapitulate human disease. Selecting the right model for specific pre-clinical research is essential for the successful completion of investigation. We here review recent and most known pre-clinical murine, transgenic and humanized models of MM, focusing on major advantages and/or weaknesses in the light of different research aims.
Lingua originaleEnglish
pagine (da-a)20119-20133
Numero di pagine15
RivistaOncotarget
Volume9
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

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