The effect of b-cyclodextrin (b-CD) on the reactivity in the base-catalyzed pathway for the rearrangement in water of some (Z)- hydrazones of 3-benzoyl-1,2,4-oxadiazoles (1b–f) into the relevant triazoles (2b–f) was investigated, finding different behavior as a function of the proton concentration. ESIMS and 1H NMR data evidence the formation of host–guest complexes. The whole of the experimental and calculated (MM2) data enabled us to draw some intriguing conclusions concerning the influence of the structures of the substrates and the nature of the formed host–guest complexes on the real site of the reaction.
|Numero di pagine||9|
|Stato di pubblicazione||Published - 2007|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry