Monocyte distribution width (MDW) as a screening tool for sepsis in the Emergency Department

Concetta Scazzone, Marcello Ciaccio, Bruna Lo Sasso, Luisa Agnello, Giulia Bivona, Rosaria Vincenza Giglio, Marcello Ciaccio, Bruna Lo Sasso, Bruna Lo Sasso, Matteo Vidali, Alessandro Iacona, Giorgia Iacolino, Silvia Mancuso

Risultato della ricerca: Articlepeer review

1 Citazioni (Scopus)

Abstract

Objectives: The diagnosis of sepsis in the EmergencyDepartment (ED) is challenging and a reliable biomarker isneeded. The current study aimed to evaluate the diagnosticaccuracy of monocyte distribution width (MDW) for theearly identification of sepsis in the ED.Methods: We performed a large observational studyincluding consecutive adult patients (≥18 years of age)presenting to the ED between September and November2019, with an order for Complete Blood Count (CBC) evaluation.A total of 2,215 patients were enrolled and classifiedbased on Sepsis-2 criteria as the control group (1,855),infection group (172), Systemic Inflammatory ResponseSyndrome (SIRS) group (100), and sepsis group (88).Results: MDW levels were higher in patients with sepsisthan in all other groups (p<0.001). ROC curve analysisshowed an optimal diagnostic accuracy of MDW for sepsisprediction at a cut-off point of 23.5, with an AUC of 0.964,sensitivity and specificity of 0.920 and 0.929, respectively.Conclusions: Our findings encourage further investigationto validate the use of MDW as a screening tool for theearly identification of patients at risk of sepsis in the ED.Keywords: Emergency Department (ED); infection; monocytes;monocyte distribution width (MDW); screening;sepsis.
Lingua originaleEnglish
Numero di pagine7
RivistaClinical Chemistry and Laboratory Medicine
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

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