Haemagglutinin sequences of pandemic influenza A(H1N1) viruses circulating inItaly were examined, focusing on amino acid changes at position 222 because ofits suggested pathogenic relevance. Among 169 patients, the D222G substitutionwas detected in three of 52 (5.8%) severe cases and in one of 117 (0.9%) mildcases, whereas the D222E mutation was more frequent and evenly distributed inmild (31.6%) and severe cases (38.4%). A cluster of D222E viruses among schoolchildren confirms reported human-to-human transmission of viruses mutated atamino acid position 222.
|Numero di pagine||0|
|Stato di pubblicazione||Published - 2010|
All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health
Vitale, F., Facchini, M., Spagnolo, D., Palmieri, Trotta, Puzelli, S., Oleari, Pompa, Donatelli, Bagnarelli, P., De Marco, Boros, Cassone, A., Azzi, Rezza, G., & Corcioli (2010). Molecular surveillance of pandemic influenza A(H1N1) viruses circulating in Italyfrom May 2009 to February 2010: association between haemagglutinin mutations and clinical outcome. Eurosurveillance, 15.