Molecular profiling of pancreatic neuroendocrine tumors (pNETS) and the clinical potential

Antonio Russo, Lorena Incorvaia, Christian Diego Rolfo, Antonio Galvano, Konstantinos Papadimitriou, Daniele Santini, Christian Rolfo, Nicola Silvestris, Daniele Santini, Marc Peeters, Konstantinos Papadimitriou, Jose Ferri, Federica D’Antonio, Amanda Nogueira, Massimiliano Camilli

Risultato della ricerca: Article

Abstract

Introduction: Pancreatic neuroendocrine tumors (pNETs) represent a small part of pancreatic neoplasms, and the knowledge about their indolent clinical course remains a subject of investigation. They occur sporadically or as part of familial cancer syndromes and are classified by WHO in 3 categories. There is ongoing research to understand their molecular profiling and leading mutations. Areas covered: The aim of this review is to clarify the overall aspects of tumorigenesis, to expose the latest developments in understanding the course of the disease and the possible therapeutic implications of these. The review also discusses functional and non-functional pNETs and associated inherited syndromes as well as pNET molecular profiling and its possible guidance in the use of targeted therapy. Expert commentary: In the next decade, a more extensive application of new technologies will help improve quality of life and survival, individualizing treatment protocols and identifying which therapeutic strategy is more suitable for each kind of NET.
Lingua originaleEnglish
pagine (da-a)471-478
Numero di pagine8
RivistaEXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
Volume12
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cita questo

Molecular profiling of pancreatic neuroendocrine tumors (pNETS) and the clinical potential. / Russo, Antonio; Incorvaia, Lorena; Rolfo, Christian Diego; Galvano, Antonio; Papadimitriou, Konstantinos; Santini, Daniele; Rolfo, Christian; Silvestris, Nicola; Santini, Daniele; Peeters, Marc; Papadimitriou, Konstantinos; Ferri, Jose; D’Antonio, Federica; Nogueira, Amanda; Camilli, Massimiliano.

In: EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, Vol. 12, 2018, pag. 471-478.

Risultato della ricerca: Article

Russo, A, Incorvaia, L, Rolfo, CD, Galvano, A, Papadimitriou, K, Santini, D, Rolfo, C, Silvestris, N, Santini, D, Peeters, M, Papadimitriou, K, Ferri, J, D’Antonio, F, Nogueira, A & Camilli, M 2018, 'Molecular profiling of pancreatic neuroendocrine tumors (pNETS) and the clinical potential', EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, vol. 12, pagg. 471-478.
Russo, Antonio ; Incorvaia, Lorena ; Rolfo, Christian Diego ; Galvano, Antonio ; Papadimitriou, Konstantinos ; Santini, Daniele ; Rolfo, Christian ; Silvestris, Nicola ; Santini, Daniele ; Peeters, Marc ; Papadimitriou, Konstantinos ; Ferri, Jose ; D’Antonio, Federica ; Nogueira, Amanda ; Camilli, Massimiliano. / Molecular profiling of pancreatic neuroendocrine tumors (pNETS) and the clinical potential. In: EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY. 2018 ; Vol. 12. pagg. 471-478.
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AU - Russo, Antonio

AU - Incorvaia, Lorena

AU - Rolfo, Christian Diego

AU - Galvano, Antonio

AU - Papadimitriou, Konstantinos

AU - Santini, Daniele

AU - Rolfo, Christian

AU - Silvestris, Nicola

AU - Santini, Daniele

AU - Peeters, Marc

AU - Papadimitriou, Konstantinos

AU - Ferri, Jose

AU - D’Antonio, Federica

AU - Nogueira, Amanda

AU - Camilli, Massimiliano

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AB - Introduction: Pancreatic neuroendocrine tumors (pNETs) represent a small part of pancreatic neoplasms, and the knowledge about their indolent clinical course remains a subject of investigation. They occur sporadically or as part of familial cancer syndromes and are classified by WHO in 3 categories. There is ongoing research to understand their molecular profiling and leading mutations. Areas covered: The aim of this review is to clarify the overall aspects of tumorigenesis, to expose the latest developments in understanding the course of the disease and the possible therapeutic implications of these. The review also discusses functional and non-functional pNETs and associated inherited syndromes as well as pNET molecular profiling and its possible guidance in the use of targeted therapy. Expert commentary: In the next decade, a more extensive application of new technologies will help improve quality of life and survival, individualizing treatment protocols and identifying which therapeutic strategy is more suitable for each kind of NET.

UR - http://hdl.handle.net/10447/295520

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