Molecular profiling of pancreatic neuroendocrine tumors (pNETS) and the clinical potential

Konstantinos Papadimitriou, Lorena Incorvaia, Antonio Russo, Antonio Galvano, Marc Peeters, Konstantinos Papadimitriou, Jose Ferri, Federica D’Antonio, Amanda Nogueira, Massimiliano Camilli, Massimiliano Camilli, Massimiliano Camilli, Christian Rolfo, Nicola Silvestris, Daniele Santini, Christian Diego Rolfo, Daniele Santini

Risultato della ricerca: Article

Abstract

Introduction: Pancreatic neuroendocrine tumors (pNETs) represent a small part of pancreatic neoplasms, and the knowledge about their indolent clinical course remains a subject of investigation. They occur sporadically or as part of familial cancer syndromes and are classified by WHO in 3 categories. There is ongoing research to understand their molecular profiling and leading mutations. Areas covered: The aim of this review is to clarify the overall aspects of tumorigenesis, to expose the latest developments in understanding the course of the disease and the possible therapeutic implications of these. The review also discusses functional and non-functional pNETs and associated inherited syndromes as well as pNET molecular profiling and its possible guidance in the use of targeted therapy. Expert commentary: In the next decade, a more extensive application of new technologies will help improve quality of life and survival, individualizing treatment protocols and identifying which therapeutic strategy is more suitable for each kind of NET.
Lingua originaleEnglish
pagine (da-a)471-478
Numero di pagine8
RivistaEXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
Volume12
Stato di pubblicazionePublished - 2018

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All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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Papadimitriou, K., Incorvaia, L., Russo, A., Galvano, A., Peeters, M., Papadimitriou, K., Ferri, J., D’Antonio, F., Nogueira, A., Camilli, M., Camilli, M., Camilli, M., Rolfo, C., Silvestris, N., Santini, D., Rolfo, C. D., & Santini, D. (2018). Molecular profiling of pancreatic neuroendocrine tumors (pNETS) and the clinical potential. EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 12, 471-478.