Abstract
| Lingua originale | Undefined/Unknown |
|---|---|
| pagine (da-a) | 659-665 |
| Numero di pagine | 7 |
| Rivista | THE JOURNAL OF PHYSIOLOGY |
| Volume | 565 |
| Stato di pubblicazione | Published - 2005 |
All Science Journal Classification (ASJC) codes
- Physiology
Cita questo
Modulatory Effects of Low- and High-Frequency Repetitive Transcranial Magnetic Stimulation on Visual Cortex of Healthy Subjects Undergoing Light Deprivation. / Brighina, Filippo; Fierro, Brigida; Daniele, Ornella; Giglia, Giuseppe; Scalia, Simona; Vitello, Giorgia; Pascual-Leone, Alvaro.
In: THE JOURNAL OF PHYSIOLOGY, Vol. 565, 2005, pag. 659-665.Risultato della ricerca: Article
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TY - JOUR
T1 - Modulatory Effects of Low- and High-Frequency Repetitive Transcranial Magnetic Stimulation on Visual Cortex of Healthy Subjects Undergoing Light Deprivation
AU - Brighina, Filippo
AU - Fierro, Brigida
AU - Daniele, Ornella
AU - Giglia, Giuseppe
AU - Scalia, Simona
AU - Vitello, Giorgia
AU - Pascual-Leone, Alvaro
PY - 2005
Y1 - 2005
N2 - The aim of the present study was to explore further the effects of light deprivation (LD) on visual cortex excitability. Healthy subjects reporting reliable induction of phosphenes by occipital transcranial magnetic stimulation (TMS) underwent 60 min of complete LD. Phosphene threshold (PT) was measured before (T0), after 45 min (T1) and 60 min (T2) of LD, and then every 10 min after light re-exposure until recovery to T0 values. Repetitive TMS (rTMS) (at 1 or 10 Hz) was applied in separate sessions during the last 15 min of LD. PTs significantly decreased after 45 min of LD. rTMS differentially modified the effects of 60 min LD on PTs depending on stimulation frequency. One hertz rTMS did not change the decreasing of PT values as observed in baseline condition, but significantly prolonged the time to recover T0 PT values after light re-exposure. By contrast, 10 Hz rTMS significantly increased PT and the time to recover T0 PT values after light re-exposure was shortened. The results of this study show that the modulatory effects of different rTMS frequencies on visual cortex critically depend on the pre-existing excitability state of inhibitory and facilitatory circuits, and provide novel insights into the neurophysiological changes that take place in the visual cortex following functional visual deafferentation.
AB - The aim of the present study was to explore further the effects of light deprivation (LD) on visual cortex excitability. Healthy subjects reporting reliable induction of phosphenes by occipital transcranial magnetic stimulation (TMS) underwent 60 min of complete LD. Phosphene threshold (PT) was measured before (T0), after 45 min (T1) and 60 min (T2) of LD, and then every 10 min after light re-exposure until recovery to T0 values. Repetitive TMS (rTMS) (at 1 or 10 Hz) was applied in separate sessions during the last 15 min of LD. PTs significantly decreased after 45 min of LD. rTMS differentially modified the effects of 60 min LD on PTs depending on stimulation frequency. One hertz rTMS did not change the decreasing of PT values as observed in baseline condition, but significantly prolonged the time to recover T0 PT values after light re-exposure. By contrast, 10 Hz rTMS significantly increased PT and the time to recover T0 PT values after light re-exposure was shortened. The results of this study show that the modulatory effects of different rTMS frequencies on visual cortex critically depend on the pre-existing excitability state of inhibitory and facilitatory circuits, and provide novel insights into the neurophysiological changes that take place in the visual cortex following functional visual deafferentation.
UR - http://hdl.handle.net/10447/29493
M3 - Article
VL - 565
SP - 659
EP - 665
JO - Journal of Physiology
JF - Journal of Physiology
SN - 0022-3751
ER -