MODULATION OF GRO-ALPHA AND TNF-ALPHA PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS TREATED WITH KILLED HELICOBACTER PYLORI

Antonio Cascio; Giovanna Stassi; null Gazzara; null Iannello; Adriana Arena; null Cascio; Gaetano Bruno Costa; Chiara Iaria

MODULATION OF GRO-ALPHA AND TNF-ALPHA PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS TREATED WITH KILLED HELICOBACTER PYLORI

Antonio Cascio, Giovanna Stassi, Gazzara, Iannello, Adriana Arena, Cascio, Gaetano Bruno Costa, Chiara Iaria

Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Risultato della ricerca: Article › peer review

16 Citazioni (Scopus)

Abstract

GRO-alpha seems to play an important role in recruiting and activating neutrophils during Helicobacter pylori infection. In the present study, we examined how treatment with killed H. pylori or/and live H. pylori may differentially influence the in vitro GRO-alpha and TNF-alpha release by peripheral blood mononuclear cells (PBMC). The amounts of TNF-alpha and GRO-alpha produced by PBMC after stimulation with live H. pylori were higher than those produced after stimulation with a combination of killed and live H. pylori and the latter were higher than those produced after stimulation with killed H. pylori. In conclusion, the treatment of peripheral blood mononuclear cells with killed H. pylori down-regulates the production of GRO-alpha. Taken together, our data demonstrate that treatment with killed H. pylori could represent an innovative approach during gastric infection supported by H. pylori.

Lingua originale	English
pagine (da-a)	83-88
Numero di pagine	6
Rivista	European Journal of Inflammation
Volume	5
Stato di pubblicazione	Published - 2007

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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title = "MODULATION OF GRO-ALPHA AND TNF-ALPHA PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS TREATED WITH KILLED HELICOBACTER PYLORI",

abstract = "GRO-alpha seems to play an important role in recruiting and activating neutrophils during Helicobacter pylori infection. In the present study, we examined how treatment with killed H. pylori or/and live H. pylori may differentially influence the in vitro GRO-alpha and TNF-alpha release by peripheral blood mononuclear cells (PBMC). The amounts of TNF-alpha and GRO-alpha produced by PBMC after stimulation with live H. pylori were higher than those produced after stimulation with a combination of killed and live H. pylori and the latter were higher than those produced after stimulation with killed H. pylori. In conclusion, the treatment of peripheral blood mononuclear cells with killed H. pylori down-regulates the production of GRO-alpha. Taken together, our data demonstrate that treatment with killed H. pylori could represent an innovative approach during gastric infection supported by H. pylori.",

author = "Antonio Cascio and Giovanna Stassi and Gazzara and Iannello and Adriana Arena and Cascio and Costa, {Gaetano Bruno} and Chiara Iaria",

year = "2007",

language = "English",

volume = "5",

pages = "83--88",

journal = "European Journal of Inflammation",

issn = "1721-727X",

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}

TY - JOUR

T1 - MODULATION OF GRO-ALPHA AND TNF-ALPHA PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS TREATED WITH KILLED HELICOBACTER PYLORI

AU - Cascio, Antonio

AU - Stassi, Giovanna

AU - Gazzara, null

AU - Iannello, null

AU - Arena, Adriana

AU - Cascio, null

AU - Costa, Gaetano Bruno

AU - Iaria, Chiara

PY - 2007

Y1 - 2007

N2 - GRO-alpha seems to play an important role in recruiting and activating neutrophils during Helicobacter pylori infection. In the present study, we examined how treatment with killed H. pylori or/and live H. pylori may differentially influence the in vitro GRO-alpha and TNF-alpha release by peripheral blood mononuclear cells (PBMC). The amounts of TNF-alpha and GRO-alpha produced by PBMC after stimulation with live H. pylori were higher than those produced after stimulation with a combination of killed and live H. pylori and the latter were higher than those produced after stimulation with killed H. pylori. In conclusion, the treatment of peripheral blood mononuclear cells with killed H. pylori down-regulates the production of GRO-alpha. Taken together, our data demonstrate that treatment with killed H. pylori could represent an innovative approach during gastric infection supported by H. pylori.

AB - GRO-alpha seems to play an important role in recruiting and activating neutrophils during Helicobacter pylori infection. In the present study, we examined how treatment with killed H. pylori or/and live H. pylori may differentially influence the in vitro GRO-alpha and TNF-alpha release by peripheral blood mononuclear cells (PBMC). The amounts of TNF-alpha and GRO-alpha produced by PBMC after stimulation with live H. pylori were higher than those produced after stimulation with a combination of killed and live H. pylori and the latter were higher than those produced after stimulation with killed H. pylori. In conclusion, the treatment of peripheral blood mononuclear cells with killed H. pylori down-regulates the production of GRO-alpha. Taken together, our data demonstrate that treatment with killed H. pylori could represent an innovative approach during gastric infection supported by H. pylori.

UR - http://hdl.handle.net/10447/378863

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M3 - Article

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EP - 88

JO - European Journal of Inflammation

JF - European Journal of Inflammation

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