MODULATION OF GRO-ALPHA AND TNF-ALPHA PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS TREATED WITH KILLED HELICOBACTER PYLORI

Antonio Cascio, Giovanna Stassi, Gazzara, Iannello, Adriana Arena, Cascio, Gaetano Bruno Costa, Chiara Iaria

Risultato della ricerca: Articlepeer review

16 Citazioni (Scopus)

Abstract

GRO-alpha seems to play an important role in recruiting and activating neutrophils during Helicobacter pylori infection. In the present study, we examined how treatment with killed H. pylori or/and live H. pylori may differentially influence the in vitro GRO-alpha and TNF-alpha release by peripheral blood mononuclear cells (PBMC). The amounts of TNF-alpha and GRO-alpha produced by PBMC after stimulation with live H. pylori were higher than those produced after stimulation with a combination of killed and live H. pylori and the latter were higher than those produced after stimulation with killed H. pylori. In conclusion, the treatment of peripheral blood mononuclear cells with killed H. pylori down-regulates the production of GRO-alpha. Taken together, our data demonstrate that treatment with killed H. pylori could represent an innovative approach during gastric infection supported by H. pylori.
Lingua originaleEnglish
pagine (da-a)83-88
Numero di pagine6
RivistaEuropean Journal of Inflammation
Volume5
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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