TY - JOUR
T1 - MODULATION OF GRO-ALPHA AND TNF-ALPHA PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS TREATED WITH KILLED HELICOBACTER PYLORI
AU - Cascio, Antonio
AU - Stassi, Giovanna
AU - Gazzara, null
AU - Iannello, null
AU - Arena, Adriana
AU - Cascio, null
AU - Costa, Gaetano Bruno
AU - Iaria, Chiara
PY - 2007
Y1 - 2007
N2 - GRO-alpha seems to play an important role in recruiting and activating neutrophils during Helicobacter pylori infection. In the present study, we examined how treatment with killed H. pylori or/and live H. pylori may differentially influence the in vitro GRO-alpha and TNF-alpha release by peripheral blood mononuclear cells (PBMC). The amounts of TNF-alpha and GRO-alpha produced by PBMC after stimulation with live H. pylori were higher than those produced after stimulation with a combination of killed and live H. pylori and the latter were higher than those produced after stimulation with killed H. pylori. In conclusion, the treatment of peripheral blood mononuclear cells with killed H. pylori down-regulates the production of GRO-alpha. Taken together, our data demonstrate that treatment with killed H. pylori could represent an innovative approach during gastric infection supported by H. pylori.
AB - GRO-alpha seems to play an important role in recruiting and activating neutrophils during Helicobacter pylori infection. In the present study, we examined how treatment with killed H. pylori or/and live H. pylori may differentially influence the in vitro GRO-alpha and TNF-alpha release by peripheral blood mononuclear cells (PBMC). The amounts of TNF-alpha and GRO-alpha produced by PBMC after stimulation with live H. pylori were higher than those produced after stimulation with a combination of killed and live H. pylori and the latter were higher than those produced after stimulation with killed H. pylori. In conclusion, the treatment of peripheral blood mononuclear cells with killed H. pylori down-regulates the production of GRO-alpha. Taken together, our data demonstrate that treatment with killed H. pylori could represent an innovative approach during gastric infection supported by H. pylori.
UR - http://hdl.handle.net/10447/378863
UR - http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=2&SID=Q2JLJJjg@@J5dJD1Kji&page=1&doc=7
M3 - Article
VL - 5
SP - 83
EP - 88
JO - European Journal of Inflammation
JF - European Journal of Inflammation
SN - 1721-727X
ER -