Modified glasgow prognostic score is associated with risk of recurrence in bladder cancer patients after radical Cystectomy: A multicenter experience

Vincenzo Serretta, Riccardo Autorino, Matteo Ferro, Gennaro Musi, Marco Borghesi, Guru Sonpavde, Carlo Buonerba, Gian Maria Busetto, Riccardo Giovannone, Luigi Castaldo, Marco Capece, Danilo Bottero, Antonio Brescia, Antonio Cioffi, Amelia Cimmino, Michele Olivieri, Ettore De Berardinis, Rodolfo Hurle, Marco Borghesi, Francesco CantielloDaniela Terracciano, Dario Bruzzese, Sisto Perdona, Vincenzo Altieri, Ottavio De Cobelli, Deliu Victor Matei, Pierluigi Bove, Michele Caraglia, Pasquale Ditonno, Vincenzo Mirone, Giuseppe Di Lorenzo, Vincenzo Serretta, Rocco Damiano, Giuseppe Lucarelli

Risultato della ricerca: Articlepeer review

27 Citazioni (Scopus)

Abstract

Recently, many studies explored the role of inflammation parameters in the prognosis of urinary cancers, but the results were not consistent. The modified Glasgow Prognostic Score (mGPS), a systemic inflammation marker, is a prognostic marker in various types of cancers. The aim of the present study was to investigate the usefulness of the preoperative mGPS as predictor of recurrence-free (RFS), overall (OS), and cancer-specific (CSS) survivals in a large cohort of urothelial bladder cancer (UBC) patients. A total of 1037 patients with UBC were included in this study with a median follow-up of 22 months (range 360 months). An mGPS0 was observed in 646 patients (62.3%), mGPS1 in 297 patients (28.6 %), and mGPS2 in 94 patients (9.1%). In our study cohort, subjects with an mGPS equal to 2 had a significantly shorter median RFS compared with subjects with mGPS equal to 1 (16 vs 19 months, hazard ratio [HR] 1.54, 95% CI 1.311.81, P<0.001) or with subjects with mGPS equal to 0 (16 vs 29 months, HR 2.38, 95% CI 1.863.05, P<0.001). The association between mGPS and RFS was confirmed by weighted multivariate Cox model. Although in univariate analysis higher mGPS was associated with lower OS and CSS, this association disappeared in multivariate analysis where only the presence of lymph node-positive bladder cancer and T4 stage were predictors of worse prognosis for OS and CSS. In conclusion, the mGPS is an easily measured and inexpensive prognostic marker that was significantly associated with RFS in UBC patients.
Lingua originaleEnglish
pagine (da-a)e1861-6
Numero di pagine6
RivistaMEDICINE
Volume94
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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