Abstract
Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer. © 2005 Hindawi Publishing Corporation.
Lingua originale | English |
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pagine (da-a) | 60-62 |
Numero di pagine | 3 |
Rivista | Mediators of Inflammation |
Volume | 2005 |
Stato di pubblicazione | Published - 2005 |
All Science Journal Classification (ASJC) codes
- ???subjectarea.asjc.2400.2403???
- ???subjectarea.asjc.1300.1307???