Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents

Elvira Ventura Spagnolo, Elvira Ventura-Spagnolo, Paola Lucia Minciullo, Concettina Fenga, Giuseppe Di Pasquale, Giovanna Spatari, Anna Cacciola, Sebastiano Gangemi

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)

Abstract

Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer. © 2005 Hindawi Publishing Corporation.
Lingua originaleEnglish
pagine (da-a)60-62
Numero di pagine3
RivistaMediators of Inflammation
Volume2005
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1307???

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