Mitochondrial DNA deletion and male infertility

Elena Carra, Anna Maria Rinaldi, Barbara Salerno

Risultato della ricerca: Otherpeer review


AbstractThe term “male infertility” does not constitute a defined clinical syndrome, but rather, a collection of different conditions exhibiting a variety of aetiologies and varying diagnosis. In men, oligozoospermia, asthenozoospermia, teratozoospermia and azoospermia are the main causes of infertility. The present research is aimed to investigate if mtDNA deletions can cause sperm defects in idiopathic astenozoospermic patients with different sperm motility and sperm concentration. The incidence of deletions in mtDNA (mtDNA) was co-related with diagnostic categorization of male infertility when 6.6kb out of the 16.6kb of the mitochondrial genome was amplified from whole sperm samples, from motile and non motile sperm fractions of the same patient. The purpose of this study was, also, to determine if the whole sperm samples is suitable to evidence the mtDNA through Long PCR.
Lingua originaleEnglish
Numero di pagine0
Stato di pubblicazionePublished - 2009


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