MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells

Alessia Lo Dico, Alice Conigliaro, Riccardo Alessandro, Alice Conigliaro, Aroldo Rizzo, Alessia Lo Dico, Francesca Rajata, Viviana Costa, Riccardo Alessandro, Marco Tripodi

Risultato della ricerca: Articlepeer review

26 Citazioni (Scopus)

Abstract

The survival rates in colon cancer patients are inversely proportional to the number of lymph node metastases. The hypoxia-induced Epithelial to Mesenchymal Transition (EMT), driven by HIF1α, is known to be involved in cancer progression and metastasis. Recently, we have reported that miR-675-5p promotes glioma growth by stabilizing HIF1α here, by use of the syngeneic cell lines we investigated the role of the miR-675-5p in colon cancer metastasis. Our results show that miR-675-5p, over expressed in metastatic colon cancer cells, participates to tumour progression by regulating HIF1α induced EMT. MiR-675- 5p increases Snail transcription by a dual strategy: i) stabilizing the activity of the transcription factor HIF1α and ii) and inhibiting Snail's repressor DDB2 (Damage specific DNA Binding protein 2). Moreover, transcriptional analyses on specimens from colon cancer patients confirmed, in vivo, the correlation between miR-675-5p over-expression and metastasis, thus identifying miR-675-5p as a new marker for colon cancer progression and therefore a putative target for therapeutic strategies.
Lingua originaleEnglish
pagine (da-a)24292-24302
Numero di pagine11
RivistaOncotarget
Volume8
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Oncology

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