MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells

Alessia Lo Dico, Alice Conigliaro, Riccardo Alessandro, Alice Conigliaro, Aroldo Rizzo, Alessia Lo Dico, Francesca Rajata, Viviana Costa, Riccardo Alessandro, Marco Tripodi

Risultato della ricerca: Article

20 Citazioni (Scopus)

Abstract

The survival rates in colon cancer patients are inversely proportional to the number of lymph node metastases. The hypoxia-induced Epithelial to Mesenchymal Transition (EMT), driven by HIF1α, is known to be involved in cancer progression and metastasis. Recently, we have reported that miR-675-5p promotes glioma growth by stabilizing HIF1α here, by use of the syngeneic cell lines we investigated the role of the miR-675-5p in colon cancer metastasis. Our results show that miR-675-5p, over expressed in metastatic colon cancer cells, participates to tumour progression by regulating HIF1α induced EMT. MiR-675- 5p increases Snail transcription by a dual strategy: i) stabilizing the activity of the transcription factor HIF1α and ii) and inhibiting Snail's repressor DDB2 (Damage specific DNA Binding protein 2). Moreover, transcriptional analyses on specimens from colon cancer patients confirmed, in vivo, the correlation between miR-675-5p over-expression and metastasis, thus identifying miR-675-5p as a new marker for colon cancer progression and therefore a putative target for therapeutic strategies.
Lingua originaleEnglish
pagine (da-a)24292-24302
Numero di pagine11
RivistaOncotarget
Volume8
Stato di pubblicazionePublished - 2017

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Epithelial-Mesenchymal Transition
Colonic Neoplasms
Neoplasm Metastasis
Snails
DNA-Binding Proteins
Glioma
Neoplasms
Transcription Factors
Survival Rate
Lymph Nodes
Hypoxia
Cell Line
Growth

All Science Journal Classification (ASJC) codes

  • Oncology

Cita questo

MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells. / Lo Dico, Alessia; Conigliaro, Alice; Alessandro, Riccardo; Conigliaro, Alice; Rizzo, Aroldo; Lo Dico, Alessia; Rajata, Francesca; Costa, Viviana; Alessandro, Riccardo; Tripodi, Marco.

In: Oncotarget, Vol. 8, 2017, pag. 24292-24302.

Risultato della ricerca: Article

Lo Dico, A, Conigliaro, A, Alessandro, R, Conigliaro, A, Rizzo, A, Lo Dico, A, Rajata, F, Costa, V, Alessandro, R & Tripodi, M 2017, 'MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells', Oncotarget, vol. 8, pagg. 24292-24302.
Lo Dico, Alessia ; Conigliaro, Alice ; Alessandro, Riccardo ; Conigliaro, Alice ; Rizzo, Aroldo ; Lo Dico, Alessia ; Rajata, Francesca ; Costa, Viviana ; Alessandro, Riccardo ; Tripodi, Marco. / MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells. In: Oncotarget. 2017 ; Vol. 8. pagg. 24292-24302.
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title = "MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells",
abstract = "The survival rates in colon cancer patients are inversely proportional to the number of lymph node metastases. The hypoxia-induced Epithelial to Mesenchymal Transition (EMT), driven by HIF1{\^I}±, is known to be involved in cancer progression and metastasis. Recently, we have reported that miR-675-5p promotes glioma growth by stabilizing HIF1{\^I}± here, by use of the syngeneic cell lines we investigated the role of the miR-675-5p in colon cancer metastasis. Our results show that miR-675-5p, over expressed in metastatic colon cancer cells, participates to tumour progression by regulating HIF1{\^I}± induced EMT. MiR-675- 5p increases Snail transcription by a dual strategy: i) stabilizing the activity of the transcription factor HIF1{\^I}± and ii) and inhibiting Snail's repressor DDB2 (Damage specific DNA Binding protein 2). Moreover, transcriptional analyses on specimens from colon cancer patients confirmed, in vivo, the correlation between miR-675-5p over-expression and metastasis, thus identifying miR-675-5p as a new marker for colon cancer progression and therefore a putative target for therapeutic strategies.",
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AU - Lo Dico, Alessia

AU - Conigliaro, Alice

AU - Alessandro, Riccardo

AU - Conigliaro, Alice

AU - Rizzo, Aroldo

AU - Lo Dico, Alessia

AU - Rajata, Francesca

AU - Costa, Viviana

AU - Alessandro, Riccardo

AU - Tripodi, Marco

PY - 2017

Y1 - 2017

N2 - The survival rates in colon cancer patients are inversely proportional to the number of lymph node metastases. The hypoxia-induced Epithelial to Mesenchymal Transition (EMT), driven by HIF1α, is known to be involved in cancer progression and metastasis. Recently, we have reported that miR-675-5p promotes glioma growth by stabilizing HIF1α here, by use of the syngeneic cell lines we investigated the role of the miR-675-5p in colon cancer metastasis. Our results show that miR-675-5p, over expressed in metastatic colon cancer cells, participates to tumour progression by regulating HIF1α induced EMT. MiR-675- 5p increases Snail transcription by a dual strategy: i) stabilizing the activity of the transcription factor HIF1α and ii) and inhibiting Snail's repressor DDB2 (Damage specific DNA Binding protein 2). Moreover, transcriptional analyses on specimens from colon cancer patients confirmed, in vivo, the correlation between miR-675-5p over-expression and metastasis, thus identifying miR-675-5p as a new marker for colon cancer progression and therefore a putative target for therapeutic strategies.

AB - The survival rates in colon cancer patients are inversely proportional to the number of lymph node metastases. The hypoxia-induced Epithelial to Mesenchymal Transition (EMT), driven by HIF1α, is known to be involved in cancer progression and metastasis. Recently, we have reported that miR-675-5p promotes glioma growth by stabilizing HIF1α here, by use of the syngeneic cell lines we investigated the role of the miR-675-5p in colon cancer metastasis. Our results show that miR-675-5p, over expressed in metastatic colon cancer cells, participates to tumour progression by regulating HIF1α induced EMT. MiR-675- 5p increases Snail transcription by a dual strategy: i) stabilizing the activity of the transcription factor HIF1α and ii) and inhibiting Snail's repressor DDB2 (Damage specific DNA Binding protein 2). Moreover, transcriptional analyses on specimens from colon cancer patients confirmed, in vivo, the correlation between miR-675-5p over-expression and metastasis, thus identifying miR-675-5p as a new marker for colon cancer progression and therefore a putative target for therapeutic strategies.

KW - CRC

KW - EMT

KW - Hypoxia

KW - Metastasis

KW - MiRNA675

KW - Oncology

UR - http://hdl.handle.net/10447/241669

UR - http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=14464&path%5B%5D=46136

M3 - Article

VL - 8

SP - 24292

EP - 24302

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

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