Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 24292-24302 |
| Numero di pagine | 11 |
| Rivista | Oncotarget |
| Volume | 8 |
| Stato di pubblicazione | Published - 2017 |
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All Science Journal Classification (ASJC) codes
- Oncology
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MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells. / Lo Dico, Alessia; Conigliaro, Alice; Alessandro, Riccardo; Conigliaro, Alice; Rizzo, Aroldo; Lo Dico, Alessia; Rajata, Francesca; Costa, Viviana; Alessandro, Riccardo; Tripodi, Marco.
In: Oncotarget, Vol. 8, 2017, pag. 24292-24302.Risultato della ricerca: Article
}
TY - JOUR
T1 - MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells
AU - Lo Dico, Alessia
AU - Conigliaro, Alice
AU - Alessandro, Riccardo
AU - Conigliaro, Alice
AU - Rizzo, Aroldo
AU - Lo Dico, Alessia
AU - Rajata, Francesca
AU - Costa, Viviana
AU - Alessandro, Riccardo
AU - Tripodi, Marco
PY - 2017
Y1 - 2017
N2 - The survival rates in colon cancer patients are inversely proportional to the number of lymph node metastases. The hypoxia-induced Epithelial to Mesenchymal Transition (EMT), driven by HIF1α, is known to be involved in cancer progression and metastasis. Recently, we have reported that miR-675-5p promotes glioma growth by stabilizing HIF1α here, by use of the syngeneic cell lines we investigated the role of the miR-675-5p in colon cancer metastasis. Our results show that miR-675-5p, over expressed in metastatic colon cancer cells, participates to tumour progression by regulating HIF1α induced EMT. MiR-675- 5p increases Snail transcription by a dual strategy: i) stabilizing the activity of the transcription factor HIF1α and ii) and inhibiting Snail's repressor DDB2 (Damage specific DNA Binding protein 2). Moreover, transcriptional analyses on specimens from colon cancer patients confirmed, in vivo, the correlation between miR-675-5p over-expression and metastasis, thus identifying miR-675-5p as a new marker for colon cancer progression and therefore a putative target for therapeutic strategies.
AB - The survival rates in colon cancer patients are inversely proportional to the number of lymph node metastases. The hypoxia-induced Epithelial to Mesenchymal Transition (EMT), driven by HIF1α, is known to be involved in cancer progression and metastasis. Recently, we have reported that miR-675-5p promotes glioma growth by stabilizing HIF1α here, by use of the syngeneic cell lines we investigated the role of the miR-675-5p in colon cancer metastasis. Our results show that miR-675-5p, over expressed in metastatic colon cancer cells, participates to tumour progression by regulating HIF1α induced EMT. MiR-675- 5p increases Snail transcription by a dual strategy: i) stabilizing the activity of the transcription factor HIF1α and ii) and inhibiting Snail's repressor DDB2 (Damage specific DNA Binding protein 2). Moreover, transcriptional analyses on specimens from colon cancer patients confirmed, in vivo, the correlation between miR-675-5p over-expression and metastasis, thus identifying miR-675-5p as a new marker for colon cancer progression and therefore a putative target for therapeutic strategies.
KW - CRC
KW - EMT
KW - Hypoxia
KW - Metastasis
KW - MiRNA675
KW - Oncology
UR - http://hdl.handle.net/10447/241669
UR - http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=14464&path%5B%5D=46136
M3 - Article
VL - 8
SP - 24292
EP - 24302
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
ER -