miR-155 regulative network in FLT3 mutated acute myeloid leukemia

Riccardo Alessandro, Stefania Raimondo, Luigi Augugliaro, Chiara Corrado, Domenico Salemi, Anna Marfia, Chiara Corrado, Maria Grazia Bica, Domenico Salemi, Valentina Randazzo, Paola Dragotto, Stefania Raimondo, Alessandra Santoro, Cecilia Agueli, Francesco Fabbiano, Riccardo Alessandro, Giuseppe Cammarata, Francesco Di Raimondo, Alessandra Santoro, Cecilia Agueli

Risultato della ricerca: Articlepeer review

16 Citazioni (Scopus)

Abstract

Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. Among AML with normal karyotype (NK-AML) FLT3 activating mutation, internal tandem duplication (FLT3-ITD), is present in about 30% of patients, conferring unfavorable outcome. Our previous data demonstrated specific up-regulation of miR-155 in FLT3-ITD+ AML. miR-155 is known to be directly implicated in normal hematopoiesis and in some pathologies such as myeloid hyperplasia and acute lymphoblastic leukemia.
Lingua originaleEnglish
pagine (da-a)883-896
Numero di pagine14
RivistaLeukemia Research
Volume39
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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