TY - JOUR
T1 - miR-155 regulative network in FLT3 mutated acute myeloid leukemia
AU - Raimondo, Stefania
AU - Augugliaro, Luigi
AU - Corrado, Chiara
AU - Salemi, Domenico
AU - Alessandro, Riccardo
AU - Marfia, Anna
AU - Corrado, Chiara
AU - Bica, Maria Grazia
AU - Salemi, Domenico
AU - Randazzo, Valentina
AU - Dragotto, Paola
AU - Raimondo, Stefania
AU - Santoro, Alessandra
AU - Randazzo, Valentina
AU - Agueli, Cecilia
AU - Randazzo, Valentina
AU - Fabbiano, Francesco
AU - Alessandro, Riccardo
AU - Cammarata, Giuseppe
AU - Di Raimondo, Francesco
AU - Santoro, Alessandra
AU - Agueli, Cecilia
PY - 2015
Y1 - 2015
N2 - Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. Among AML with normal karyotype (NK-AML) FLT3 activating mutation, internal tandem duplication (FLT3-ITD), is present in about 30% of patients, conferring unfavorable outcome. Our previous data demonstrated specific up-regulation of miR-155 in FLT3-ITD+ AML. miR-155 is known to be directly implicated in normal hematopoiesis and in some pathologies such as myeloid hyperplasia and acute lymphoblastic leukemia.
AB - Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. Among AML with normal karyotype (NK-AML) FLT3 activating mutation, internal tandem duplication (FLT3-ITD), is present in about 30% of patients, conferring unfavorable outcome. Our previous data demonstrated specific up-regulation of miR-155 in FLT3-ITD+ AML. miR-155 is known to be directly implicated in normal hematopoiesis and in some pathologies such as myeloid hyperplasia and acute lymphoblastic leukemia.
UR - http://hdl.handle.net/10447/145096
UR - http://www.sciencedirect.com/science/article/pii/S0145212615001289
M3 - Article
VL - 39
SP - 883
EP - 896
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
ER -