Minimal clinically important difference for asthma endpoints: An expert consensus report

Nicola Scichilone, Enrico Heffler, Gianenrico Senna, Marco Caminati, Diego Bagnasco, Giorgio W. Canonica, Matteo Bonini, Stefano Del Giacco, Marco Contoli, Manlio Milanese, Marcello Di Paolo, Elisiana Carpagnano, Ilaria Menichini, Ilaria Baiardini, Angelo Corsico, Carlo Lombardi, Fulvio Braido

Risultato della ricerca: Articlepeer review

7 Citazioni (Scopus)


Minimal clinically important difference (MCID) can be defined as the smallest change or difference in an outcome measure that is perceived as beneficial and would lead to a change in the patient’s medical management. The aim of the current expert consensus report is to provide a “state-of-the-art” review of the currently available literature evidence about MCID for end-points to monitor asthma control, in order to facilitate optimal disease management and identify unmet needs in the field to guide future research. A series of MCID cut-offs are currently available in literature and validated among populations of asthmatic patients, with most of the evidence focusing on outcomes as patient reported outcomes, lung function and exercise tolerance. On the contrary, only scant and partial data are available for inflammatory biomarkers. These clearly represent the most interesting target for future development in diagnosis and clinical management of asthma, particularly in view of the several biologic drugs in the pipeline, for which regulatory agencies will soon require personalised proof of efficacy and treatment response predictors.
Lingua originaleEnglish
Numero di pagine14
RivistaEuropean Respiratory Review
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2740???


Entra nei temi di ricerca di 'Minimal clinically important difference for asthma endpoints: An expert consensus report'. Insieme formano una fingerprint unica.

Cita questo