Mild cognitive impairment in Parkinson's disease: the Parkinson's disease cognitive study (PACOS)

Vincenzo Restivo, Brigida Fierro, Roberto Monastero, Antonina Luca, Calogero Edoardo Cicero, Chiara Zangara, Chiara Zangara, Chiara Zangara, Mario Zappia, Alessandra Nicoletti, Marco Davi', Roberta Baschi

Risultato della ricerca: Articlepeer review

68 Citazioni (Scopus)


Approximately 30% of Parkinson's disease (PD) patients show impaired cognitive performance, which is suggestive of Mild Cognitive Impairment (MCI), representinga predictor of dementia, especially when present at diagnosis. The objective of the study was to evaluate the frequency and clinical predictors of MCI in a largehospital-based cohort of PD patients. We collected cross-sectional data from the Parkinson's disease cognitive impairment study (PACOS), a multicenter studyinvolving two Movement Disorder centers, which are located in south Italy. The PD subjects were diagnosed according to the UK Brain Bank criteria and theyunderwent an extensive neuropsychological assessment. PD-MCI was diagnosed according to the Movement Disorder Society task force criteria for MCI. PDseverity was evaluated in accordance with the Unified PD Rating Scale-Motor Examination (UPDRS-ME) and the Hoehn and Yahr scales. The study included 659 PDpatients (57.5% men; mean age 67.0 ± 9.7 years), with a mean disease duration of 3.8 ± 4.6 years and a mean UPRDS-ME score of 25.8 ± 12.3. PD-MCI was diagnosed in 261 (39.6%) subjects and in 82 (31.7%) of 259 newly diagnosed patients (disease duration ≤ 1 year). An amnestic MCI multidomain phenotype was the most frequent MCI subtype (39.1% of the overall sample and 43.9% in newly diagnosed PD). A positive significant association between MCI, age and motor scores was found at multivariate logistic regression analysis, while a negative association was observed between educational level and MCI. In conclusion and in agreement with the literature data, the prevalence of MCI recorded in the PACOS sample was approximately 40 and 32% amongst newly diagnosed patients.
Lingua originaleEnglish
pagine (da-a)1050-1058
Numero di pagine9
RivistaJournal of Neurology
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

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