Migraine in children under 6 years of age: A long-term follow-up study

Salvatore Mangano, Filippo Brighina, Rosaria Nardello, Giuseppe Donato Mangano, Vincenzo Raieli, Francesca Vanadia, Luca Maria Messina

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4 Citazioni (Scopus)


Background: Early starting of migraine seems predictive for less favorable outcome in later ages, howeverfollow-up investigations are very few and all with short-term prospective period. We report here thelongest follow-up study in a population of children presenting with migraine under the age of 6.Methods: We followed-up 74 children under 6 years of age, referred for headache to our departmentbetween 1997 and 2003. The study was carried out between October 2016 and March 2018. Headachediagnoses were made according to the IHS criteria.Results: 23/74 patients, 31% of the original cohort, were found at follow-up in a period ranging between15 to 21 years after the first visit. Seven of them were headache free. The remaining 16 patients hadmigraine. In the migraine group, the localization of pain changed in 75% of the subjects, 11/16 (68.7%) hadallodynia and 9/16 (56.25%) had cranial autonomic symptoms.Conclusions: Our results suggest that the onset of migraine at very young age represents unfavorableprognostic factor for persistence of the disease at later ages. Some clinical features may change duringclinical course, and the active persistence of the disorder may lead to an increase in allodynia.
Lingua originaleEnglish
Numero di pagine5
RivistaEuropean Journal of Paediatric Neurology
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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