Microfluidic production of hyaluronic acid derivative microfibers to control drug release

Giovanna Pitarresi; Fabio Salvatore Palumbo; Stefano Agnello; Gaetano Giammona; João F. Mano; Luca Gasperini; Rui L. Reis; Rui L. Reis; Luca Gasperini; Giovanna Pitarresi; Gaetano Giammona

Microfluidic production of hyaluronic acid derivative microfibers to control drug release

Giovanna Pitarresi, Fabio Salvatore Palumbo, Stefano Agnello, Gaetano Giammona, João F. Mano, Luca Gasperini, Rui L. Reis, Rui L. Reis, Luca Gasperini, Giovanna Pitarresi, Gaetano Giammona

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

18 Citazioni (Scopus)

Abstract

Microfibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability of the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.

Lingua originale	English
pagine (da-a)	309-313
Numero di pagine	5
Rivista	Materials Letters
Volume	182
Stato di pubblicazione	Published - 2016

All Science Journal Classification (ASJC) codes

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title = "Microfluidic production of hyaluronic acid derivative microfibers to control drug release",

abstract = "Microfibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability of the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.",

keywords = "Biomaterials, Condensed Matter Physics, Drug delivery, Hyaluronic acid, Materials Science (all), Mechanical Engineering, Mechanics of Materials, Microfibers, Microfluidic technique, Polymers, Biomaterials, Condensed Matter Physics, Drug delivery, Hyaluronic acid, Materials Science (all), Mechanical Engineering, Mechanics of Materials, Microfibers, Microfluidic technique, Polymers",

author = "Giovanna Pitarresi and Palumbo, {Fabio Salvatore} and Stefano Agnello and Gaetano Giammona and Mano, {Jo{\~a}o F.} and Luca Gasperini and Reis, {Rui L.} and Reis, {Rui L.} and Luca Gasperini and Giovanna Pitarresi and Gaetano Giammona",

year = "2016",

language = "English",

volume = "182",

pages = "309--313",

journal = "Materials Letters",

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T1 - Microfluidic production of hyaluronic acid derivative microfibers to control drug release

AU - Pitarresi, Giovanna

AU - Palumbo, Fabio Salvatore

AU - Agnello, Stefano

AU - Giammona, Gaetano

AU - Mano, João F.

AU - Gasperini, Luca

AU - Reis, Rui L.

AU - Gasperini, Luca

AU - Pitarresi, Giovanna

AU - Giammona, Gaetano

PY - 2016

Y1 - 2016

N2 - Microfibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability of the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.

AB - Microfibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability of the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.

KW - Biomaterials

KW - Condensed Matter Physics

KW - Drug delivery

KW - Hyaluronic acid

KW - Materials Science (all)

KW - Mechanical Engineering

KW - Mechanics of Materials

KW - Microfibers

KW - Microfluidic technique

KW - Polymers

KW - Biomaterials

KW - Condensed Matter Physics

KW - Drug delivery

KW - Hyaluronic acid

KW - Materials Science (all)

KW - Mechanical Engineering

KW - Mechanics of Materials

KW - Microfibers

KW - Microfluidic technique

KW - Polymers

UR - http://hdl.handle.net/10447/193341

UR - http://www.journals.elsevier.com/materials-letters/

M3 - Article

SN - 0167-577X

VL - 182

SP - 309

EP - 313

JO - Materials Letters

JF - Materials Letters

ER -

Microfluidic production of hyaluronic acid derivative microfibers to control drug release

Abstract

All Science Journal Classification (ASJC) codes

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