Microfluidic production of hyaluronic acid derivative microfibers to control drug release

Gaetano Giammona, Giovanna Pitarresi, Fabio Salvatore Palumbo, Stefano Agnello, Giovanna Pitarresi, Gaetano Giammona, João F. Mano, Luca Gasperini, Rui L. Reis

Risultato della ricerca: Article

7 Citazioni (Scopus)

Abstract

Microfibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability of the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.
Lingua originaleEnglish
pagine (da-a)309-313
Numero di pagine5
RivistaMaterials Letters
Volume182
Stato di pubblicazionePublished - 2016

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microfibers
Hyaluronic acid
Hyaluronic Acid
Microfluidics
Dexamethasone
drugs
Salts
Derivatives
acids
Ionic strength
Drug delivery
Pharmaceutical Preparations
Buffers
Phosphates
baths
Molecules
salts
activity (biology)
delivery
phosphates

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanical Engineering
  • Mechanics of Materials
  • Condensed Matter Physics

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Microfluidic production of hyaluronic acid derivative microfibers to control drug release. / Giammona, Gaetano; Pitarresi, Giovanna; Palumbo, Fabio Salvatore; Agnello, Stefano; Pitarresi, Giovanna; Giammona, Gaetano; Mano, João F.; Gasperini, Luca; Reis, Rui L.

In: Materials Letters, Vol. 182, 2016, pag. 309-313.

Risultato della ricerca: Article

Giammona, Gaetano ; Pitarresi, Giovanna ; Palumbo, Fabio Salvatore ; Agnello, Stefano ; Pitarresi, Giovanna ; Giammona, Gaetano ; Mano, João F. ; Gasperini, Luca ; Reis, Rui L. / Microfluidic production of hyaluronic acid derivative microfibers to control drug release. In: Materials Letters. 2016 ; Vol. 182. pagg. 309-313.
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AU - Agnello, Stefano

AU - Pitarresi, Giovanna

AU - Giammona, Gaetano

AU - Mano, João F.

AU - Gasperini, Luca

AU - Reis, Rui L.

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